FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - human protein (Function)
 
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FKBP1A »  Peptidyl-prolyl cis-trans isomerase FKBP1A   [ EC 5.2.1.8 ]  (PPIase FKBP1A)
 
Protein also known as:  12 kDa FK506-binding protein (FKBP-12).
Gene name:  FKBP1A
Family name: FKBP-type PPIase » FKBP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 1
GENE REF ISO

Function

 show evidences
Overview 
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
2
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • IPIBHF-UCL
Not  Calcium channel inhibitor activitydefinition[GO:0019855]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899] silver  
  • IEAOrtholog Compara
FK506 bindingdefinition[GO:0005528]  
3
  • NASBHF-UCL
  • IDAMGI
Hsp70 protein bindingdefinition[GO:0030544] silver  
  • IEAOrtholog Compara
Ion channel bindingdefinition[GO:0044325]  
  • ISSOrtholog Curator
Macrolide bindingdefinition[GO:0005527]  
1
  • NASBHF-UCL
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
4
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Contributes to ryanodine-sensitive calcium-release channel activitydefinition[GO:0005219]  
1
  • TASBHF-UCL
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
SMAD bindingdefinition[GO:0046332]  
1
  • IPIBHF-UCL
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • ISSBHF-UCL
Contributes to transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
1
  • TASBHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
1
  • ISSBHF-UCL
GO biological process 
'de novo' protein foldingdefinition[GO:0006458]  
1
  • TASBHF-UCL
Beta-amyloid formationdefinition[GO:0034205]  
1
  • IDABHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • TASGOC
Cytokine-mediated signaling pathwaydefinition[GO:0019221] silver  
  • IEAOrtholog Compara
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • IDABHF-UCL
Heart morphogenesisdefinition[GO:0003007]  
  • ISSOrtholog Curator
Heart trabecula formationdefinition[GO:0060347]  
  • ISSOrtholog Curator
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Muscle contractiondefinition[GO:0006936] silver  
  • IEAOrtholog Compara
Negative regulation of protein phosphatase type 2B activitydefinition[GO:0032513]  
1
  • IDABHF-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
  • IEAOrtholog Compara
Not  Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280]  
1
  • IDABHF-UCL
Not  Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
1
  • IDABHF-UCL
Peptidyl-proline modificationdefinition[GO:0018208] silver  
  • IBARefGenome
Phosphorylationdefinition[GO:0016310]  
1
  • TASGOC
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • IDABHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDABHF-UCL
Protein foldingdefinition[GO:0006457]  
1
  • NASUniProtKB
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • TASBHF-UCL
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
4
  • TASGOC
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASGOC
Protein refoldingdefinition[GO:0042026]  
1
  • TASBHF-UCL
Regulation of activin receptor signaling pathwaydefinition[GO:0032925]  
1
  • IDABHF-UCL
Regulation of immune responsedefinition[GO:0050776]  
1
  • IMPBHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Release of sequestered calcium ion into cytosoldefinition[GO:0051209] silver  
  • IEAOrtholog Compara
Response to caffeinedefinition[GO:0031000] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
SMAD protein complex assemblydefinition[GO:0007183]  
1
  • IDABHF-UCL
T cell activationdefinition[GO:0042110]  
1
  • NASBHF-UCL
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
Transmembrane transportdefinition[GO:0055085]  
1
  • TASGOC
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FKBP1A
GenomeRNAi: 2280
PRO: PR:P62942
Chemistry
GuidetoPHARMACOLOGY: 2609