FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - human protein (Function)
 
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FKBP1A »  Peptidyl-prolyl cis-trans isomerase FKBP1A   [ EC 5.2.1.8 ]  (PPIase FKBP1A)
 
Protein also known as:  12 kDa FK506-binding protein (FKBP-12).
Gene name:  FKBP1A
Family name: FKBP-type PPIase » FKBP1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
2
  • CuratedUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FKBP1A
GenomeRNAi: 2280
PRO: PR:P62942
Chemistry
GuidetoPHARMACOLOGY: 2609