FKBP1A - Peptidyl-prolyl cis-trans isomerase FKBP1A - human protein (Function)
 
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FKBP1A »  Peptidyl-prolyl cis-trans isomerase FKBP1A   [ EC 5.2.1.8 ]  (PPIase FKBP1A)
 
Protein also known as:  12 kDa FK506-binding protein (FKBP-12).
Gene name:  FKBP1A
Family name: FKBP-type PPIase » FKBP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 87 1
GENE REF ISO

Function

 show evidences
Overview 
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
3
  • UniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • BHF-UCL
Not  Calcium channel inhibitor activitydefinition[GO:0019855]  
1
  • BHF-UCL
FK506 bindingdefinition[GO:0005528]  
3
  • BHF-UCL
  • MGI
Ion channel bindingdefinition[GO:0044325]  
2
  • BHF-UCL
  • Ortholog Curator
Macrolide bindingdefinition[GO:0005527]  
1
  • BHF-UCL
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
4
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
  • ParkinsonsUK-UCL
  • UniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • UniProtKB
SMAD bindingdefinition[GO:0046332]  
1
  • BHF-UCL
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
2
  • BHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
1
  • BHF-UCL
GO biological process 
'de novo' protein foldingdefinition[GO:0006458]  
1
  • BHF-UCL
Amyloid fibril formationdefinition[GO:1990000]  
1
  • BHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • BHF-UCL
Chaperone-mediated protein foldingdefinition[GO:0061077]  
1
  • RefGenome
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • BHF-UCL
Heart morphogenesisdefinition[GO:0003007]  
1
  • Ortholog Curator
Heart trabecula formationdefinition[GO:0060347]  
1
  • Ortholog Curator
Negative regulation of protein phosphatase type 2B activitydefinition[GO:0032513]  
1
  • BHF-UCL
Not  Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280]  
1
  • BHF-UCL
Not  Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
1
  • BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • UniProtKB
Positive regulation of protein bindingdefinition[GO:0032092]  
1
  • BHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • BHF-UCL
Protein foldingdefinition[GO:0006457]  
1
  • UniProtKB
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • BHF-UCL
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
1
  • BHF-UCL
Protein refoldingdefinition[GO:0042026]  
1
  • BHF-UCL
Regulation of activin receptor signaling pathwaydefinition[GO:0032925]  
1
  • BHF-UCL
Regulation of amyloid precursor protein catabolic processdefinition[GO:1902991]  
1
  • ParkinsonsUK-UCL
Regulation of immune responsedefinition[GO:0050776]  
1
  • BHF-UCL
Regulation of protein localizationdefinition[GO:0032880]  
1
  • ParkinsonsUK-UCL
Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
2
  • BHF-UCL
  • Ortholog Curator
SMAD protein complex assemblydefinition[GO:0007183]  
1
  • BHF-UCL
T cell activationdefinition[GO:0042110]  
1
  • BHF-UCL
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
TGF-beta receptor signaling activates SMADs  REACT_120850  
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)  REACT_120726  
TGFBR1 KD Mutants in Cancer  REACT_169263  
TGFBR1 LBD Mutants in Cancer  REACT_169445  
TGFBR2 Kinase Domain Mutants in Cancer  REACT_169440  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FKBP1A
GenomeRNAi: 2280
PRO: PR:P62942
Chemistry
GuidetoPHARMACOLOGY: 2609