CACNG7 - Voltage-dependent calcium channel gamma-7 subunit - human protein (Function)
 
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CACNG7 »  Voltage-dependent calcium channel gamma-7 subunit
 
Protein also known as:  Neuronal voltage-gated calcium channel gamma-7 subunit.
Gene name:  CACNG7
Family name: PMP-22/EMP/MP20 » CACNG
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(+) channel auxiliary subunit 1-8 (cca) family  8.A.16.2.5  
GO molecular function 
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • NASUniProtKB
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • NASUniProtKB
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+59284  
Cardiac muscle contraction  hsa04260+59284  
Dilated cardiomyopathy  hsa05414+59284  
Hypertrophic cardiomyopathy (HCM)  hsa05410+59284  
MAPK signaling pathway  hsa04010+59284  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 59284
PRO: PR:P62955