RPS27A - Ubiquitin-40S ribosomal protein S27a - human protein (Function)
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RPS27A »  Ubiquitin-40S ribosomal protein S27a
Protein also known as:  Ubiquitin carboxyl extension protein 80. Cleaved into:  40S ribosomal protein S27a; Ubiquitin.
Gene name:  RPS27A
Family names: In the N-terminal section Ubiquitin
In the C-terminal section Ribosomal protein S27Ae
Entry whose protein(s) existence is based on evidence at protein level
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Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.  
  • UniProtKB
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.  
  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
  • IntAct
Structural constituent of ribosomedefinition[GO:0003735]  
  • UniProtKB
GO biological process 
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+6233  
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_286692  
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_118614  
activated TAK1 mediates p38 MAPK activation  REACT_21399  
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon  REACT_25148  
Activation of NF-kappaB in B cells  REACT_118656  
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
APC-Cdc20 mediated degradation of Nek2A  REACT_8017  
APC/C:Cdc20 mediated degradation of Cyclin B  REACT_6820  
APC/C:Cdc20 mediated degradation of Securin  REACT_6871  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Assembly Of The HIV Virion  REACT_6818  
Association of licensing factors with the pre-replicative complex  REACT_1181  
Asymmetric localization of PCP proteins  REACT_264478  
AUF1 (hnRNP D0) destabilizes mRNA  REACT_25325  
Autodegradation of Cdh1 by Cdh1:APC/C  REACT_6785  
Autodegradation of the E3 ubiquitin ligase COP1  REACT_20549  
Budding and maturation of HIV virion  REACT_6359  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  REACT_6850  
CDK-mediated phosphorylation and removal of Cdc6  REACT_1221  
CDT1 association with the CDC6:ORC:origin complex  REACT_1949  
Circadian Clock  REACT_24941  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  REACT_115852  
Constitutive Signaling by NOTCH1 HD Domain Mutants  REACT_160089  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Cyclin D associated events in G1  REACT_821  
deactivation of the beta-catenin transactivating complex  REACT_264178  
degradation of AXIN  REACT_263873  
Degradation of beta-catenin by the destruction complex  REACT_11063  
degradation of DVL  REACT_264438  
Degradation of GLI1 by the proteasome  REACT_268156  
Degradation of GLI2 by the proteasome  REACT_267700  
Downregulation of ERBB2:ERBB3 signaling  REACT_115662  
Downregulation of ERBB4 signaling  REACT_115828  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
Downregulation of TGF-beta receptor signaling  REACT_120727  
Downstream TCR signaling  REACT_12555  
EGFR downregulation  REACT_12484  
Endosomal Sorting Complex Required For Transport (ESCRT)  REACT_27258  
ER-Phagosome pathway  REACT_111178  
Eukaryotic Translation Termination  REACT_1986  
Fanconi Anemia pathway  REACT_18410  
FCERI mediated NF-kB activation  REACT_163994  
Formation of a pool of free 40S subunits  REACT_1797  
Formation of the ternary complex, and subsequently, the 43S complex  REACT_1079  
GLI3 is processed to GLI3R by the proteasome  REACT_268366  
Glycogen synthesis  REACT_169208  
GTP hydrolysis and joining of the 60S ribosomal subunit  REACT_2085  
Hedgehog 'on' state  REACT_268718  
Hedgehog ligand biogenesis  REACT_264605  
Hh ligand biogenesis disease  REACT_263883  
IKK complex recruitment mediated by RIP1  REACT_25374  
Interleukin-1 signaling  REACT_22442  
IRAK1 recruits IKK complex  REACT_24918  
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation  REACT_25354  
IRAK2 mediated activation of TAK1 complex  REACT_25380  
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation  REACT_25018  
ISG15 antiviral mechanism  REACT_115831  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  REACT_21368  
L13a-mediated translational silencing of Ceruloplasmin expression  REACT_79  
Membrane binding and targetting of GAG proteins  REACT_115893  
Myoclonic epilepsy of Lafora  REACT_264430  
Negative regulation of FGFR signaling  REACT_111184  
Negative regulators of RIG-I/MDA5 signaling  REACT_25271  
NF-kB is activated and signals survival  REACT_13696  
NOD1/2 Signaling Pathway  REACT_75776  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  REACT_75822  
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)  REACT_75768  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
NOTCH2 Activation and Transmission of Signal to the Nucleus  REACT_160205  
NRIF signals cell death from the nucleus  REACT_13643  
Oncogene Induced Senescence  REACT_169325  
Orc1 removal from chromatin  REACT_1156  
Oxidative Stress Induced Senescence  REACT_169436  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  REACT_120916  
p75NTR recruits signalling complexes  REACT_13415  
Peptide chain elongation  REACT_1404  
Regulation of activated PAK-2p34 by proteasome mediated degradation  REACT_13464  
regulation of FZD by ubiquitination  REACT_264580  
Regulation of innate immune responses to cytosolic DNA  REACT_163977  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Regulation of signaling by CBL  REACT_23787  
Regulation of the Fanconi anemia pathway  REACT_18265  
Ribosomal scanning and start codon recognition  REACT_931  
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways  REACT_25359  
SCF(Skp2)-mediated degradation of p27/p21  REACT_9003  
SCF-beta-TrCP mediated degradation of Emi1  REACT_6821  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
Separation of Sister Chromatids  REACT_150471  
Signaling by ERBB2  REACT_115755  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
Spry regulation of FGF signaling  REACT_111080  
SRP-dependent cotranslational protein targeting to membrane  REACT_115902  
Stimuli-sensing channels  REACT_160189  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  REACT_21281  
TCF dependent signaling in response to WNT  REACT_264596  
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)  REACT_120726  
TRAF6 mediated induction of TAK1 complex  REACT_25351  
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  REACT_25120  
Translation initiation complex formation  REACT_1979  
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A  REACT_1614  
Ubiquitin-dependent degradation of Cyclin D1  REACT_4  
Vif-mediated degradation of APOBEC3G  REACT_9453  
Viral mRNA Translation  REACT_9491  
Vpu mediated degradation of CD4  REACT_9031  
Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.  
  • UniProtKB
For a better understanding, features related to ubiquitin are only indicated for the first chain.  
  • UniProtKB


Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: RPS27A
GenomeRNAi: 6233
PRO: PR:P62979