RPS27A - Ubiquitin-40S ribosomal protein S27a - human protein (Function)
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RPS27A »  Ubiquitin-40S ribosomal protein S27a
Protein also known as:  Ubiquitin carboxyl extension protein 80. Cleaved into:  40S ribosomal protein S27a; Ubiquitin.
Gene name:  RPS27A
Family names: In the N-terminal section Ubiquitin
In the C-terminal section Ribosomal protein S27Ae
Entry whose protein(s) existence is based on evidence at protein level
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Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.  
  • CuratedUniProtKB
Ribosomal protein S27a is a component of the 40S subunit of the ribosome.  
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
  • IDAUniProtKB
Structural constituent of ribosomedefinition[GO:0003735]  
  • IDAUniProtKB
GO biological process 
  • ICUniProtKB
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+6233  
According to Reactome, this protein belongs to the following pathways:
3' -UTR-mediated translational regulation  REACT_1762  
APC-Cdc20 mediated degradation of Nek2A  REACT_8017  
Apoptosis  REACT_578  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  REACT_6850  
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
Circadian Clock  REACT_24941  
Disease  REACT_224568  
Disease  REACT_189085  
Disease  REACT_116125  
DNA Repair  REACT_216  
DNA Replication  REACT_383  
Gene Expression  REACT_71  
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
Metabolism of RNA  REACT_21257  
Mitotic M-M/G1 phases  REACT_21300  
Proteasome mediated degradation of PAK-2p34  REACT_13505  
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor  REACT_2001  
Signal Transduction  REACT_205386  
Signal Transduction  REACT_111102  
Signal Transduction  REACT_188257  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
Transmembrane transport of small molecules  REACT_15518  
Ubiquitination of PAK-2p34  REACT_13487  
Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.  
  • CuratedUniProtKB
For a better understanding, features related to ubiquitin are only indicated for the first chain.  
  • CuratedUniProtKB


Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: RPS27A
GenomeRNAi: 6233
PRO: PR:P62979