RPS27A - Ubiquitin-40S ribosomal protein S27a - human protein (Function)
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RPS27A »  Ubiquitin-40S ribosomal protein S27a
Protein also known as:  Ubiquitin carboxyl extension protein 80. Cleaved into:  40S ribosomal protein S27a; Ubiquitin.
Gene name:  RPS27A
Family names: In the N-terminal section Ubiquitin
In the C-terminal section Ribosomal protein S27Ae
Entry whose protein(s) existence is based on evidence at protein level
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Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.  
  • UniProtKB
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.  
  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • UniProtKB KW
Poly(A) RNA bindingdefinition[GO:0044822]  
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
  • IntAct
Structural constituent of ribosomedefinition[GO:0003735]  
  • UniProtKB
GO biological process 
  • UniProtKB
According to KEGG, this protein belongs to the following pathway:
Ribosome  hsa03010+6233  
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  R-MMU-2122948  
Activated NOTCH1 Transmits Signal to the Nucleus  R-HSA-2122948  
activated TAK1 mediates p38 MAPK activation  R-HSA-450302  
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon  R-HSA-936964  
Activation of NF-kappaB in B cells  R-HSA-1169091  
Antigen processing: Ubiquitination & Proteasome degradation  R-HSA-983168  
APC-Cdc20 mediated degradation of Nek2A  R-HSA-179409  
APC/C:Cdc20 mediated degradation of Cyclin B  R-HSA-174048  
APC/C:Cdc20 mediated degradation of Securin  R-HSA-174154  
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  R-HSA-174178  
Assembly Of The HIV Virion  R-HSA-175474  
Association of licensing factors with the pre-replicative complex  R-HSA-69298  
Asymmetric localization of PCP proteins  R-HSA-4608870  
AUF1 (hnRNP D0) destabilizes mRNA  R-HSA-450408  
Autodegradation of Cdh1 by Cdh1:APC/C  R-HSA-174084  
Autodegradation of the E3 ubiquitin ligase COP1  R-HSA-349425  
Budding and maturation of HIV virion  R-HSA-162588  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  R-HSA-174184  
CDK-mediated phosphorylation and removal of Cdc6  R-HSA-69017  
CDT1 association with the CDC6:ORC:origin complex  R-HSA-68827  
Circadian Clock  R-HSA-400253  
CLEC7A (Dectin-1) signaling  R-HSA-5607764  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
Constitutive Signaling by NOTCH1 HD Domain Mutants  R-HSA-2691232  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  R-HSA-2894862  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  R-HSA-2644606  
Cyclin D associated events in G1  R-HSA-69231  
deactivation of the beta-catenin transactivating complex  R-HSA-3769402  
Dectin-1 mediated noncanonical NF-kB signaling  R-HSA-5607761  
degradation of AXIN  R-HSA-4641257  
Degradation of beta-catenin by the destruction complex  R-HSA-195253  
degradation of DVL  R-HSA-4641258  
Degradation of GLI1 by the proteasome  R-HSA-5610780  
Degradation of GLI2 by the proteasome  R-HSA-5610783  
Downregulation of ERBB2:ERBB3 signaling  R-HSA-1358803  
Downregulation of ERBB4 signaling  R-HSA-1253288  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  R-HSA-2173795  
Downregulation of TGF-beta receptor signaling  R-HSA-2173788  
Downstream TCR signaling  R-HSA-202424  
EGFR downregulation  R-HSA-182971  
Endosomal Sorting Complex Required For Transport (ESCRT)  R-HSA-917729  
ER-Phagosome pathway  R-HSA-1236974  
Eukaryotic Translation Termination  R-HSA-72764  
Fanconi Anemia pathway  R-HSA-419524  
FCERI mediated NF-kB activation  R-HSA-2871837  
Formation of a pool of free 40S subunits  R-HSA-72689  
Formation of the ternary complex, and subsequently, the 43S complex  R-HSA-72695  
G2/M DNA damage checkpoint  R-HSA-69473  
GLI3 is processed to GLI3R by the proteasome  R-HSA-5610785  
Glycogen synthesis  R-HSA-3322077  
GTP hydrolysis and joining of the 60S ribosomal subunit  R-HSA-72706  
Hedgehog 'on' state  R-HSA-5632684  
Hedgehog ligand biogenesis  R-HSA-5358346  
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD  R-HSA-5362768  
IKK complex recruitment mediated by RIP1  R-HSA-937041  
Interleukin-1 signaling  R-HSA-446652  
IRAK1 recruits IKK complex  R-HSA-937039  
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation  R-HSA-975144  
IRAK2 mediated activation of TAK1 complex  R-HSA-937042  
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation  R-HSA-975163  
ISG15 antiviral mechanism  R-HSA-1169408  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  R-HSA-450321  
L13a-mediated translational silencing of Ceruloplasmin expression  R-HSA-156827  
MAPK6/MAPK4 signaling  R-HSA-5687128  
Membrane binding and targetting of GAG proteins  R-HSA-174490  
Myoclonic epilepsy of Lafora  R-HSA-3785653  
Negative regulation of FGFR1 signaling  R-HSA-5654726  
Negative regulation of FGFR2 signaling  R-HSA-5654727  
Negative regulation of FGFR3 signaling  R-HSA-5654732  
Negative regulation of FGFR4 signaling  R-HSA-5654733  
Negative regulation of MAPK pathway  R-HSA-5675221  
Negative regulators of RIG-I/MDA5 signaling  R-HSA-936440  
NF-kB is activated and signals survival  R-HSA-209560  
NIK-->noncanonical NF-kB signaling  R-HSA-5676590  
NOD1/2 Signaling Pathway  R-HSA-168638  
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)  R-HSA-975957  
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)  R-HSA-975956  
NOTCH1 Intracellular Domain Regulates Transcription  R-HSA-2122947  
NOTCH2 Activation and Transmission of Signal to the Nucleus  R-HSA-2979096  
NRIF signals cell death from the nucleus  R-HSA-205043  
Oncogene Induced Senescence  R-HSA-2559585  
Orc1 removal from chromatin  R-HSA-68949  
Oxidative Stress Induced Senescence  R-HSA-2559580  
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha  R-HSA-1234176  
p75NTR recruits signalling complexes  R-HSA-209543  
Peptide chain elongation  R-HSA-156902  
Recognition of DNA damage by PCNA-containing replication complex  R-HSA-110314  
Regulation of activated PAK-2p34 by proteasome mediated degradation  R-HSA-211733  
regulation of FZD by ubiquitination  R-HSA-4641263  
Regulation of innate immune responses to cytosolic DNA  R-HSA-3134975  
Regulation of necroptotic cell death  R-HSA-5675482  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
Regulation of RAS by GAPs  R-HSA-5658442  
Regulation of signaling by CBL  R-HSA-912631  
Regulation of the Fanconi anemia pathway  R-HSA-419552  
Ribosomal scanning and start codon recognition  R-HSA-72702  
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways  R-HSA-168928  
SCF(Skp2)-mediated degradation of p27/p21  R-HSA-187577  
SCF-beta-TrCP mediated degradation of Emi1  R-HSA-174113  
Senescence-Associated Secretory Phenotype (SASP)  R-HSA-2559582  
Separation of Sister Chromatids  R-HSA-2467813  
Signaling by ERBB2  R-HSA-1227986  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  R-HSA-2173796  
Spry regulation of FGF signaling  R-HSA-1295596  
SRP-dependent cotranslational protein targeting to membrane  R-HSA-1799339  
Stimuli-sensing channels  R-HSA-2672351  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  R-HSA-445989  
TCF dependent signaling in response to WNT  R-HSA-201681  
Termination of translesion DNA synthesis  R-HSA-5656169  
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)  R-HSA-2173791  
TNFR2 non-canonical NF-kB pathway  R-HSA-5668541  
TRAF6 mediated induction of TAK1 complex  R-HSA-937072  
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  R-HSA-975110  
Translation initiation complex formation  R-HSA-72649  
Translesion Synthesis by POLH  R-HSA-110320  
Translesion synthesis by POLI  R-HSA-5656121  
Translesion synthesis by POLK  R-HSA-5655862  
Translesion synthesis by REV1  R-HSA-110312  
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A  R-HSA-69601  
Ubiquitin-dependent degradation of Cyclin D1  R-HSA-69229  
Vif-mediated degradation of APOBEC3G  R-HSA-180585  
Viral mRNA Translation  R-HSA-192823  
Vpu mediated degradation of CD4  R-HSA-180534  
Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.  
  • UniProtKB
For a better understanding, features related to ubiquitin are only indicated for the first chain.  
  • UniProtKB


Molecular function 
Ribonucleoprotein  definition   [KW-0687]
Ribosomal protein  definition   [KW-0689]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: RPS27A
GenomeRNAi: 6233
PRO: PR:P62979