GRB2 - Growth factor receptor-bound protein 2 - human protein (Function)
 
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GRB2 »  Growth factor receptor-bound protein 2
 
Protein also known as:  SH2/SH3 adapter GRB2.
Gene name:  GRB2
Family name: GRB2/sem-5/DRK
Entry whose protein(s) existence is based on evidence at protein level
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1 321 2
GENE REF ISO

Function

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Overview 
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.  
3
  • CuratedUniProtKB
Isoform  Iso 2   Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.  
3
  • CuratedUniProtKB
Isoform  Iso 2   Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element.  
3
  • CuratedUniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • IPIUniProtKB
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • IPIUniProtKB
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Insulin receptor substrate bindingdefinition[GO:0043560]  
1
  • IPIUniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • IPIUniProtKB
Phosphotyrosine bindingdefinition[GO:0001784] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
108
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • IDAUniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Anatomical structure formation involved in morphogenesisdefinition[GO:0048646] silver  
  • IEAOrtholog Compara
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASUniProtKB
Cellular response to ionizing radiationdefinition[GO:0071479]  
1
  • IMPBHF-UCL
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • TASUniProtKB
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • IPIUniProtKB
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
  • IEAOrtholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IMPBHF-UCL
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
  • IEAOrtholog Compara
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IMPBHF-UCL
Regulation of MAPK cascadedefinition[GO:0043408] silver  
  • IEAOrtholog Compara
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • IMPBHF-UCL
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+2885  
B cell receptor signaling pathway  hsa04662+2885  
Chemokine signaling pathway  hsa04062+2885  
Chronic myeloid leukemia  hsa05220+2885  
Dorso-ventral axis formation  hsa04320+2885  
Endometrial cancer  hsa05213+2885  
ErbB signaling pathway  hsa04012+2885  
Fc epsilon RI signaling pathway  hsa04664+2885  
Focal adhesion  hsa04510+2885  
Gap junction  hsa04540+2885  
Glioma  hsa05214+2885  
GnRH signaling pathway  hsa04912+2885  
Hepatitis C  hsa05160+2885  
Insulin signaling pathway  hsa04910+2885  
Jak-STAT signaling pathway  hsa04630+2885  
MAPK signaling pathway  hsa04010+2885  
Natural killer cell mediated cytotoxicity  hsa04650+2885  
Neurotrophin signaling pathway  hsa04722+2885  
Non-small cell lung cancer  hsa05223+2885  
Osteoclast differentiation  hsa04380+2885  
Pathways in cancer  hsa05200+2885  
Renal cell carcinoma  hsa05211+2885  
T cell receptor signaling pathway  hsa04660+2885  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
CD28 dependent Vav1 pathway  REACT_19238  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Costimulation by the CD28 family  REACT_19344  
DAP12 signaling  REACT_147814  
Downstream signal transduction  REACT_17025  
EGFR downregulation  REACT_12484  
EGFR Transactivation by Gastrin  REACT_121096  
FCERI mediated Ca+2 mobilization  REACT_163834  
FCERI mediated MAPK activation  REACT_163701  
FRS2-mediated cascade  REACT_21247  
GAB1 signalosome  REACT_12578  
GRB2 events in EGFR signaling  REACT_12606  
GRB2 events in ERBB2 signaling  REACT_115854  
Interleukin receptor SHC signaling  REACT_23891  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
NCAM signaling for neurite out-growth  REACT_18334  
Negative regulation of FGFR signaling  REACT_111184  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PI3K events in ERBB2 signaling  REACT_116008  
PIP3 activates AKT signaling  REACT_75829  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Regulation of KIT signaling  REACT_111225  
Regulation of signaling by CBL  REACT_23787  
Role of LAT2/NTAL/LAB on calcium mobilization  REACT_163769  
SHC-mediated cascade  REACT_21374  
SHC-mediated signalling  REACT_661  
SHC1 events in EGFR signaling  REACT_12579  
SHC1 events in ERBB2 signaling  REACT_115993  
SHC1 events in ERBB4 signaling  REACT_116005  
Signal attenuation  REACT_508  
Signal regulatory protein (SIRP) family interactions  REACT_23916  
Signaling by constitutively active EGFR  REACT_115852  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR1 fusion mutants  REACT_121141  
Signaling by SCF-KIT  REACT_111040  
Signalling to RAS  REACT_12033  
SOS-mediated signalling  REACT_524  
Spry regulation of FGF signaling  REACT_111080  
Tie2 Signaling  REACT_12621  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRB2
GenomeRNAi: 2885
PRO: PR:P62993