GRB2 - Growth factor receptor-bound protein 2 - human protein (Function)
 
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GRB2 »  Growth factor receptor-bound protein 2
 
Protein also known as:  Adapter protein GRB2.
Gene name:  GRB2
Family name: GRB2/sem-5/DRK
Entry whose protein(s) existence is based on evidence at protein level
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1 286 2
GENE REF ISO

Function

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Overview 
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.  
3
  • CuratedUniProtKB
Isoform  Iso 2   Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.  
3
  • CuratedUniProtKB
Isoform  Iso 2   Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element.  
3
  • CuratedUniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • IPIUniProtKB
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • IPIUniProtKB
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Insulin receptor substrate bindingdefinition[GO:0043560]  
1
  • IPIUniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • IPIUniProtKB
Phosphotyrosine bindingdefinition[GO:0001784] silver  
  • IEAOrtholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
107
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • IDAUniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Anatomical structure formation involved in morphogenesisdefinition[GO:0048646] silver  
  • IEAOrtholog Compara
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASUniProtKB
Cellular response to ionizing radiationdefinition[GO:0071479]  
1
  • IMPBHF-UCL
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • TASUniProtKB
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • IPIUniProtKB
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
  • IEAOrtholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IMPBHF-UCL
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • TASUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IMPBHF-UCL
Regulation of MAPK cascadedefinition[GO:0043408] silver  
  • IEAOrtholog Compara
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • IMPBHF-UCL
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+2885  
B cell receptor signaling pathway  hsa04662+2885  
Chemokine signaling pathway  hsa04062+2885  
Chronic myeloid leukemia  hsa05220+2885  
Dorso-ventral axis formation  hsa04320+2885  
Endometrial cancer  hsa05213+2885  
ErbB signaling pathway  hsa04012+2885  
Fc epsilon RI signaling pathway  hsa04664+2885  
Focal adhesion  hsa04510+2885  
Gap junction  hsa04540+2885  
Glioma  hsa05214+2885  
GnRH signaling pathway  hsa04912+2885  
Hepatitis C  hsa05160+2885  
Insulin signaling pathway  hsa04910+2885  
Jak-STAT signaling pathway  hsa04630+2885  
MAPK signaling pathway  hsa04010+2885  
Natural killer cell mediated cytotoxicity  hsa04650+2885  
Neurotrophin signaling pathway  hsa04722+2885  
Non-small cell lung cancer  hsa05223+2885  
Osteoclast differentiation  hsa04380+2885  
Pathways in cancer  hsa05200+2885  
Renal cell carcinoma  hsa05211+2885  
T cell receptor signaling pathway  hsa04660+2885  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRB2
GenomeRNAi: 2885
PRO: PR:P62993