GRB2 - Growth factor receptor-bound protein 2 - human protein (Function)
 
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Protein
Gene
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GRB2 »  Growth factor receptor-bound protein 2
 
Protein also known as:  Adapter protein GRB2.
Gene name:  GRB2
Family name: GRB2/sem-5/DRK
Entry whose protein(s) existence is based on evidence at protein level
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1 314 2
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.  
1
  • UniProtKB
Isoform  Iso 2   Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.  
1
  • UniProtKB
Isoform  Iso 2   Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element.  
  • UniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
1
  • UniProtKB
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
3
  • IntAct
Insulin receptor substrate bindingdefinition[GO:0043560]  
1
  • UniProtKB
Neurotrophin TRKA receptor bindingdefinition[GO:0005168]  
1
  • UniProtKB
Phosphotyrosine bindingdefinition[GO:0001784] silver  
1
  • Ortholog Compara
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
118
  • IntAct
  • UniProtKB
  • HGNC
  • WormBase
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Protein phosphatase bindingdefinition[GO:0019903] silver  
1
  • Ortholog Compara
SH3 domain bindingdefinition[GO:0017124]  
1
  • UniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • UniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Anatomical structure formation involved in morphogenesisdefinition[GO:0048646] silver  
1
  • Ortholog Compara
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • UniProtKB
Cellular response to ionizing radiationdefinition[GO:0071479]  
1
  • BHF-UCL
Epidermal growth factor receptor signaling pathwaydefinition[GO:0007173]  
1
  • UniProtKB
Insulin receptor signaling pathwaydefinition[GO:0008286]  
1
  • UniProtKB
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
1
  • Ortholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • BHF-UCL
Positive regulation of signal transductiondefinition[GO:0009967]  
3
  • GOC
  • Ortholog Compara
  • InterPro 2 GO
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Ras protein signal transductiondefinition[GO:0007265]  
1
  • UniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • BHF-UCL
Regulation of MAPK cascadedefinition[GO:0043408] silver  
1
  • Ortholog Compara
Signal transduction in response to DNA damagedefinition[GO:0042770]  
1
  • BHF-UCL
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+2885  
B cell receptor signaling pathway  hsa04662+2885  
Chemokine signaling pathway  hsa04062+2885  
Chronic myeloid leukemia  hsa05220+2885  
Dorso-ventral axis formation  hsa04320+2885  
Endometrial cancer  hsa05213+2885  
ErbB signaling pathway  hsa04012+2885  
Fc epsilon RI signaling pathway  hsa04664+2885  
Focal adhesion  hsa04510+2885  
Gap junction  hsa04540+2885  
Glioma  hsa05214+2885  
GnRH signaling pathway  hsa04912+2885  
Hepatitis C  hsa05160+2885  
Insulin signaling pathway  hsa04910+2885  
Jak-STAT signaling pathway  hsa04630+2885  
MAPK signaling pathway  hsa04010+2885  
Natural killer cell mediated cytotoxicity  hsa04650+2885  
Neurotrophin signaling pathway  hsa04722+2885  
Non-small cell lung cancer  hsa05223+2885  
Osteoclast differentiation  hsa04380+2885  
Pathways in cancer  hsa05200+2885  
Renal cell carcinoma  hsa05211+2885  
T cell receptor signaling pathway  hsa04660+2885  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
CD28 dependent Vav1 pathway  R-HSA-389359  
Constitutive Signaling by Aberrant PI3K in Cancer  R-HSA-2219530  
Constitutive Signaling by EGFRvIII  R-HSA-5637810  
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants  R-HSA-1236382  
Costimulation by the CD28 family  R-HSA-388841  
DAP12 signaling  R-HSA-2424491  
Downstream signal transduction  R-HSA-186763  
EGFR downregulation  R-HSA-182971  
EGFR Transactivation by Gastrin  R-HSA-2179392  
FCERI mediated Ca+2 mobilization  R-HSA-2871809  
FCERI mediated MAPK activation  R-HSA-2871796  
FRS-mediated FGFR1 signaling  R-HSA-5654693  
FRS-mediated FGFR2 signaling  R-HSA-5654700  
FRS-mediated FGFR3 signaling  R-HSA-5654706  
FRS-mediated FGFR4 signaling  R-HSA-5654712  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GAB1 signalosome  R-HSA-180292  
GPVI-mediated activation cascade  R-HSA-114604  
GRB2 events in EGFR signaling  R-HSA-179812  
GRB2 events in ERBB2 signaling  R-HSA-1963640  
GRB2:SOS provides linkage to MAPK signaling for Integrins  R-HSA-354194  
Insulin receptor signalling cascade  R-HSA-74751  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-3, 5 and GM-CSF signaling  R-HSA-512988  
NCAM signaling for neurite out-growth  R-HSA-375165  
Negative regulation of FGFR1 signaling  R-HSA-5654726  
Negative regulation of FGFR2 signaling  R-HSA-5654727  
Negative regulation of FGFR3 signaling  R-HSA-5654732  
Negative regulation of FGFR4 signaling  R-HSA-5654733  
PI-3K cascade:FGFR1  R-HSA-5654689  
PI-3K cascade:FGFR2  R-HSA-5654695  
PI-3K cascade:FGFR3  R-HSA-5654710  
PI-3K cascade:FGFR4  R-HSA-5654720  
PI3K Cascade  R-HSA-109704  
PI3K events in ERBB2 signaling  R-HSA-1963642  
PIP3 activates AKT signaling  R-HSA-1257604  
RAF/MAP kinase cascade  R-HSA-5673001  
Regulation of actin dynamics for phagocytic cup formation  R-HSA-2029482  
Regulation of KIT signaling  R-HSA-1433559  
Regulation of signaling by CBL  R-HSA-912631  
RHO GTPases Activate WASPs and WAVEs  R-HSA-5663213  
Role of LAT2/NTAL/LAB on calcium mobilization  R-HSA-2730905  
SHC-mediated cascade:FGFR1  R-HSA-5654688  
SHC-mediated cascade:FGFR2  R-HSA-5654699  
SHC-mediated cascade:FGFR3  R-HSA-5654704  
SHC-mediated cascade:FGFR4  R-HSA-5654719  
SHC-related events triggered by IGF1R  R-HSA-2428933  
SHC1 events in EGFR signaling  R-HSA-180336  
SHC1 events in ERBB2 signaling  R-HSA-1250196  
SHC1 events in ERBB4 signaling  R-HSA-1250347  
Signal attenuation  R-HSA-74749  
Signal regulatory protein (SIRP) family interactions  R-HSA-391160  
Signaling by FGFR1 fusion mutants  R-HSA-1839117  
Signaling by FGFR1 in disease  R-HSA-5655302  
Signaling by FGFR2 in disease  R-HSA-5655253  
Signaling by FGFR3 in disease  R-HSA-5655332  
Signaling by FGFR4 in disease  R-HSA-5655291  
Signaling by SCF-KIT  R-HSA-1433557  
Signalling to RAS  R-HSA-167044  
SOS-mediated signalling  R-HSA-112412  
Spry regulation of FGF signaling  R-HSA-1295596  
Tie2 Signaling  R-HSA-210993  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GRB2
GenomeRNAi: 2885
PRO: PR:P62993