SKP1 - S-phase kinase-associated protein 1 - human protein (Function)
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SKP1 »  S-phase kinase-associated protein 1
Protein also known as:  Transcription elongation factor B polypeptide 1-like.
Gene name:  SKP1
Family name: SKP1
Entry whose protein(s) existence is based on evidence at protein level
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Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.  
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IntAct
  • UniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
  • UniProtKB
GO biological process 
Histone H2A monoubiquitinationdefinition[GO:0035518]  
  • UniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
  • UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031146]  
  • UniProtKB
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+6500  
Circadian rhythm - mammal  hsa04710+6500  
Herpes simplex infection  hsa05168+6500  
Oocyte meiosis  hsa04114+6500  
Protein processing in endoplasmic reticulum  hsa04141+6500  
TGF-beta signaling pathway  hsa04350+6500  
Ubiquitin mediated proteolysis  hsa04120+6500  
Wnt signaling pathway  hsa04310+6500  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  R-HSA-1169091  
Antigen processing: Ubiquitination & Proteasome degradation  R-HSA-983168  
Circadian Clock  R-HSA-400253  
CLEC7A (Dectin-1) signaling  R-HSA-5607764  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  R-HSA-2894862  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  R-HSA-2644606  
Cyclin D associated events in G1  R-HSA-69231  
Dectin-1 mediated noncanonical NF-kB signaling  R-HSA-5607761  
Degradation of beta-catenin by the destruction complex  R-HSA-195253  
Degradation of GLI1 by the proteasome  R-HSA-5610780  
Degradation of GLI2 by the proteasome  R-HSA-5610783  
Downstream TCR signaling  R-HSA-202424  
FCERI mediated NF-kB activation  R-HSA-2871837  
GLI3 is processed to GLI3R by the proteasome  R-HSA-5610785  
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling  R-HSA-2644607  
MAP3K8 (TPL2)-dependent MAPK1/3 activation  R-HSA-5684264  
NIK-->noncanonical NF-kB signaling  R-HSA-5676590  
NOTCH1 Intracellular Domain Regulates Transcription  R-HSA-2122947  
Prolactin receptor signaling  R-HSA-1170546  
Regulation of PLK1 Activity at G2/M Transition  R-HSA-2565942  
SCF(Skp2)-mediated degradation of p27/p21  R-HSA-187577  
SCF-beta-TrCP mediated degradation of Emi1  R-HSA-174113  
Vpu mediated degradation of CD4  R-HSA-180534  


Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: SKP1A
GenomeRNAi: 6500
PRO: PR:P63208