SKP1 - S-phase kinase-associated protein 1 - human protein (Function)
 
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Protein
Gene
References

 
SKP1 »  S-phase kinase-associated protein 1
 
Gene name:  SKP1
Family name: SKP1
Entry whose protein(s) existence is based on evidence at protein level
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1 89 2
GENE REF ISO

Function

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Overview 
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2. SCF(FBXO10) direct ubiquitination of BCL2.  
4
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
31
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Histone H2A monoubiquitinationdefinition[GO:0035518]  
1
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDAUniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031146]  
2
  • IDAUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+6500  
Circadian rhythm - mammal  hsa04710+6500  
Herpes simplex infection  hsa05168+6500  
Oocyte meiosis  hsa04114+6500  
Protein processing in endoplasmic reticulum  hsa04141+6500  
TGF-beta signaling pathway  hsa04350+6500  
Ubiquitin mediated proteolysis  hsa04120+6500  
Wnt signaling pathway  hsa04310+6500  
According to Reactome, this protein belongs to the following pathways:
Activation of NF-kappaB in B cells  REACT_118656  
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
Circadian Clock  REACT_24941  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
Cyclin D associated events in G1  REACT_821  
Interleukin-1 signaling  REACT_22442  
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling  REACT_160305  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
Prolactin receptor signaling  REACT_115697  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
SCF(Skp2)-mediated degradation of p27/p21  REACT_9003  
SCF-beta-TrCP mediated degradation of Emi1  REACT_6821  
Vpu mediated degradation of CD4  REACT_9031  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SKP1A
GenomeRNAi: 6500
PRO: PR:P63208