GNGT1 - Guanine nucleotide-binding protein G(T) subunit gamma-T1 - human protein (Function)
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GNGT1 »  Guanine nucleotide-binding protein G(T) subunit gamma-T1
Protein also known as:  Transducin gamma chain.
Gene name:  GNGT1
Family name: G protein gamma
Entry whose protein(s) existence is based on evidence at protein level
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Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
  • CuratedUniProtKB
GO molecular function 
GTPase activitydefinition[GO:0003924]  
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Cardiac muscle cell apoptotic processdefinition[GO:0010659] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Eye photoreceptor cell developmentdefinition[GO:0042462] silver  
  • IEAOrtholog Compara
GTP catabolic processdefinition[GO:0006184]  
Protein localizationdefinition[GO:0008104] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2792  
Cholinergic synapse  hsa04725+2792  
Dopaminergic synapse  hsa04728+2792  
GABAergic synapse  hsa04727+2792  
Glutamatergic synapse  hsa04724+2792  
Phototransduction  hsa04744+2792  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Activation of the phototransduction cascade  REACT_163932  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
ADP signalling through P2Y purinoceptor 12  REACT_20653  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Ca2+ pathway  REACT_172761  
G alpha (12/13) signalling events  REACT_18407  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
G beta:gamma signalling through PLC beta  REACT_19145  
G-protein activation  REACT_15457  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
Inactivation, recovery and regulation of the phototransduction cascade  REACT_163919  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Olfactory Signaling Pathway  REACT_15488  
Presynaptic function of Kainate receptors  REACT_21254  
Prostacyclin signalling through prostacyclin receptor  REACT_23946  
Regulation of water balance by renal Aquaporins  REACT_24023  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  


Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: GNGT1
GenomeRNAi: 2792
PRO: PR:P63211