GNB2L1 - Guanine nucleotide-binding protein subunit beta-2-like 1 - human protein (Function)
 
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GNB2L1 »  Guanine nucleotide-binding protein subunit beta-2-like 1
 
Protein also known as:  Guanine nucleotide-binding protein subunit beta-like protein 12.3. Cleaved into:  Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed.
Gene name:  GNB2L1
Entry whose protein(s) existence is based on evidence at protein level
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1 166 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA.  
19
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activator activity involved in apoptotic processdefinition[GO:0008656]  
1
  • IMPUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Ion channel inhibitor activitydefinition[GO:0008200]  
  • ISSOrtholog Curator
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • TASBHF-UCL
Protein kinase C bindingdefinition[GO:0005080]  
1
  • IDAUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
Protein tyrosine kinase inhibitor activitydefinition[GO:0030292]  
1
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • NASUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IDAUniProtKB
SH2 domain bindingdefinition[GO:0042169]  
2
  • IDAUniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IMPUniProtKB
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Gastrulationdefinition[GO:0007369]  
  • IEAUniProtKB KW
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAUniProtKB
Negative regulation of phagocytosisdefinition[GO:0050765]  
1
  • IMPUniProtKB
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • IMPUniProtKB
Negative regulation of protein tyrosine kinase activitydefinition[GO:0061099]  
1
  • IDAGOC
Negative regulation of translationdefinition[GO:0017148]  
  • ISSOrtholog Curator
Negative regulation of Wnt signaling pathwaydefinition[GO:0030178]  
  • ISSOrtholog Curator
Positive regulation of apoptotic processdefinition[GO:0043065]  
2
  • IDAUniProtKB
Positive regulation of cAMP catabolic processdefinition[GO:0030822]  
1
  • IMPBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IDAUniProtKB
Positive regulation of cyclic-nucleotide phosphodiesterase activitydefinition[GO:0051343]  
1
  • IMPBHF-UCL
Positive regulation of gastrulationdefinition[GO:2000543]  
  • ISSOrtholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • IDAUniProtKB
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
1
  • IMPUniProtKB
Positive regulation of mitochondrial depolarizationdefinition[GO:0051901]  
1
  • IMPUniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436]  
1
  • IDAUniProtKB
Positive regulation of protein homooligomerizationdefinition[GO:0032464]  
2
  • IDAUniProtKB
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
2
  • IDAUniProtKB
Regulation of cell cycledefinition[GO:0051726]  
1
  • IDAUniProtKB
Regulation of cell divisiondefinition[GO:0051302]  
  • ISSOrtholog Curator
Regulation of establishment of cell polaritydefinition[GO:2000114]  
  • ISSOrtholog Curator
Regulation of establishment of protein localization to plasma membranedefinition[GO:0090003] silver  
  • IEAOrtholog Compara
Regulation of protein localizationdefinition[GO:0032880]  
  • ISSOrtholog Curator
Rhythmic processdefinition[GO:0048511]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Measles  hsa05162+10399  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Biological rhythms  definition   [KW-0090]
Cell cycle  definition   [KW-0131]
Gastrulation  definition   [KW-0306]
Growth regulation  definition   [KW-0341]
Host-virus interaction  definition   [KW-0945]
Translation regulation  definition   [KW-0810]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNB2L1
GenomeRNAi: 10399
PRO: PR:P63244