KCNJ2 - Inward rectifier potassium channel 2 - human protein (Function)
 
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KCNJ2 »  Inward rectifier potassium channel 2
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 2.
Gene name:  KCNJ2
Entry whose protein(s) existence is based on evidence at protein level
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1 98 1
GENE REF ISO

Function

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Overview 
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.2  
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Inward rectifier potassium channel activitydefinition[GO:0005242]  
3
  • IDAUniProtKB
  • IDABHF-UCL
Phosphatidylinositol-4,5-bisphosphate bindingdefinition[GO:0005546]  
1
  • IDABHF-UCL
Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarizationdefinition[GO:0086008]  
1
  • IMPBHF-UCL
GO biological process 
Cardiac muscle cell action potential involved in contractiondefinition[GO:0086002]  
1
  • IMPBHF-UCL
Cellular potassium ion homeostasisdefinition[GO:0030007]  
1
  • TASBHF-UCL
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Magnesium ion transportdefinition[GO:0015693] silver  
  • IEAOrtholog Compara
Membrane depolarization during cardiac muscle cell action potentialdefinition[GO:0086012]  
1
  • TASBHF-UCL
Membrane repolarization during action potentialdefinition[GO:0086011]  
1
  • IMPBHF-UCL
Membrane repolarization during cardiac muscle cell action potentialdefinition[GO:0086013]  
2
  • TASBHF-UCL
Positive regulation of potassium ion transmembrane transportdefinition[GO:1901381] silver  
  • IEAOrtholog Compara
Potassium ion importdefinition[GO:0010107]  
1
  • IDABHF-UCL
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDABHF-UCL
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAUniProtKB
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of membrane repolarizationdefinition[GO:0060306]  
1
  • IDABHF-UCL
Regulation of resting membrane potentialdefinition[GO:0060075]  
1
  • TASBHF-UCL
Regulation of skeletal muscle contraction via regulation of action potentialdefinition[GO:0014861]  
1
  • IMPBHF-UCL
Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • IMPBHF-UCL
Relaxation of skeletal muscledefinition[GO:0090076]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+3759  
Gastric acid secretion  hsa04971+3759  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Classical Kir channels  REACT_75870  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Kir2.1
GenomeRNAi: 3759
PRO: PR:P63252
Chemistry
GuidetoPHARMACOLOGY: 430