ACTG1 - Actin, cytoplasmic 2 - human protein (Function)
 
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Protein
Gene
References

 
ACTG1 »  Actin, cytoplasmic 2
 
Protein also known as:  Gamma-actin. Cleaved into:  Actin, cytoplasmic 2, N-terminally processed.
Gene name:  ACTG1
Family name: Actin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
3
  • IntAct
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • ParkinsonsUK-UCL
GO biological process 
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • UniProtKB
Platelet aggregationdefinition[GO:0070527]  
1
  • UniProtKB
Retina homeostasisdefinition[GO:0001895]  
1
  • UniProtKB
Sarcomere organizationdefinition[GO:0045214] silver  
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  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+71  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+71  
Bacterial invasion of epithelial cells  hsa05100+71  
Dilated cardiomyopathy  hsa05414+71  
Focal adhesion  hsa04510+71  
Hypertrophic cardiomyopathy (HCM)  hsa05410+71  
Influenza A  hsa05164+71  
Leukocyte transendothelial migration  hsa04670+71  
Pathogenic Escherichia coli infection  hsa05130+71  
Phagosome  hsa04145+71  
Regulation of actin cytoskeleton  hsa04810+71  
Salmonella infection  hsa05132+71  
Shigellosis  hsa05131+71  
Tight junction  hsa04530+71  
Vibrio cholerae infection  hsa05110+71  
Viral myocarditis  hsa05416+71  
According to Reactome, this protein belongs to the following pathways:
Adherens junctions interactions  REACT_19195  
Cell-extracellular matrix interactions  REACT_20649  
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPHB-mediated forward signaling  REACT_263952  
Formation of annular gap junctions  REACT_11049  
Gap junction degradation  REACT_11035  
Interaction between L1 and Ankyrins  REACT_22266  
Recycling pathway of L1  REACT_22365  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
VEGFA-VEGFR2 Pathway  REACT_264464  
Note 
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACTG1
GenomeRNAi: 71
PRO: PR:P63261