ACTC1 - Actin, alpha cardiac muscle 1 - human protein (Function)
 
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ACTC1 »  Actin, alpha cardiac muscle 1
 
Protein also known as:  Alpha-cardiac actin.
Gene name:  ACTC1
Family name: Actin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 1
GENE REF ISO

Function

 show evidences
Overview 
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
ATPase activitydefinition[GO:0016887]  
2
  • IDAUniProtKB
Myosin bindingdefinition[GO:0017022]  
2
  • IDABHF-UCL
  • IPIUniProtKB
GO biological process 
Actin filament-based movementdefinition[GO:0030048]  
1
  • IDAUniProtKB
Actin-myosin filament slidingdefinition[GO:0033275]  
1
  • IMPBHF-UCL
Actomyosin structure organizationdefinition[GO:0031032]  
  • ISSOrtholog Curator
Apoptotic processdefinition[GO:0006915]  
  • ISSOrtholog Curator
ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
Cardiac muscle contractiondefinition[GO:0060048] silver  
  • IEAOrtholog Compara
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
  • ISSOrtholog Curator
Cardiac myofibril assemblydefinition[GO:0055003]  
  • ISSOrtholog Curator
Heart contractiondefinition[GO:0060047]  
3
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Skeletal muscle thin filament assemblydefinition[GO:0030240]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cardiac muscle contraction  hsa04260+70  
Dilated cardiomyopathy  hsa05414+70  
Hypertrophic cardiomyopathy (HCM)  hsa05410+70  
According to Reactome, this protein belongs to the following pathway:
Striated Muscle Contraction  REACT_16969  
Note 
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACTC1
GenomeRNAi: 70
PRO: PR:P68032