FKBP1B - Peptidyl-prolyl cis-trans isomerase FKBP1B - human protein (Function)
 
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FKBP1B »  Peptidyl-prolyl cis-trans isomerase FKBP1B   [ EC 5.2.1.8 ]  (PPIase FKBP1B)
 
Protein also known as:  12.6 kDa FK506-binding protein (FKBP-12.6).
Gene name:  FKBP1B
Family name: FKBP-type PPIase » FKBP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

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Overview 
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
  • CuratedUniProtKB
GO molecular function 
Calcium channel inhibitor activitydefinition[GO:0019855]  
2
  • IDABHF-UCL
Cyclic nucleotide bindingdefinition[GO:0030551] silver  
  • IEAOrtholog Compara
FK506 bindingdefinition[GO:0005528]  
1
  • IDABHF-UCL
Ion channel bindingdefinition[GO:0044325]  
  • ISSOrtholog Curator
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
2
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
2
  • IPIBHF-UCL
Contributes to ryanodine-sensitive calcium-release channel activitydefinition[GO:0005219]  
1
  • TASBHF-UCL
GO biological process 
'de novo' protein foldingdefinition[GO:0006458]  
1
  • TASBHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • TASGOC
Calcium-mediated signaling using intracellular calcium sourcedefinition[GO:0035584]  
1
  • TASBHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • TASBHF-UCL
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
2
  • IGIBHF-UCL
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Negative regulation of heart ratedefinition[GO:0010459]  
  • ISSOrtholog Curator
Negative regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061179] silver  
  • IEAOrtholog Compara
Negative regulation of protein phosphatase type 2B activitydefinition[GO:0032513]  
1
  • IDABHF-UCL
Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280]  
1
  • IDABHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
1
  • IDABHF-UCL
Neuronal action potential propagationdefinition[GO:0019227] silver  
  • IEAOrtholog Compara
Positive regulation of axon regenerationdefinition[GO:0048680] silver  
  • IEAOrtholog Compara
Positive regulation of sequestering of calcium iondefinition[GO:0051284]  
1
  • IDABHF-UCL
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • TASBHF-UCL
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
2
  • IDABHF-UCL
  • IDAGOC
Protein refoldingdefinition[GO:0042026]  
1
  • TASBHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
  • ISSOrtholog Curator
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0010880]  
1
  • IDABHF-UCL
Contradiction  Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
3
  • IDABHF-UCL
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0014808] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Response to redox statedefinition[GO:0051775]  
1
  • IDABHF-UCL
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Smooth muscle contractiondefinition[GO:0006939] silver  
  • IEAOrtholog Compara
T cell proliferationdefinition[GO:0042098] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP1B
GenomeRNAi: 2281
PRO: PR:P68106