FKBP1B - Peptidyl-prolyl cis-trans isomerase FKBP1B - human protein (Function)
 
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FKBP1B »  Peptidyl-prolyl cis-trans isomerase FKBP1B   [ EC 5.2.1.8 ]  (PPIase FKBP1B)
 
Protein also known as:  12.6 kDa FK506-binding protein (FKBP-12.6).
Gene name:  FKBP1B
Family name: FKBP-type PPIase » FKBP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
Overview 
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
1
  • UniProtKB
GO molecular function 
Calcium channel inhibitor activitydefinition[GO:0019855]  
2
  • BHF-UCL
Cyclic nucleotide bindingdefinition[GO:0030551] silver  
1
  • Ortholog Compara
FK506 bindingdefinition[GO:0005528]  
1
  • BHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • Ortholog Curator
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
2
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • BHF-UCL
Receptor bindingdefinition[GO:0005102]  
2
  • BHF-UCL
Contributes to ryanodine-sensitive calcium-release channel activitydefinition[GO:0005219]  
1
  • BHF-UCL
GO biological process 
'de novo' protein foldingdefinition[GO:0006458]  
1
  • BHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • GOC
Calcium-mediated signaling using intracellular calcium sourcedefinition[GO:0035584]  
1
  • BHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
1
  • BHF-UCL
Chaperone-mediated protein foldingdefinition[GO:0061077]  
1
  • RefGenome
Cytosolic calcium ion homeostasisdefinition[GO:0051480]  
2
  • BHF-UCL
Insulin secretiondefinition[GO:0030073] silver  
1
  • Ortholog Compara
Negative regulation of heart ratedefinition[GO:0010459]  
1
  • Ortholog Curator
Negative regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061179] silver  
1
  • Ortholog Compara
Negative regulation of protein phosphatase type 2B activitydefinition[GO:0032513]  
1
  • BHF-UCL
Negative regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051280]  
1
  • BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
1
  • BHF-UCL
Neuronal action potential propagationdefinition[GO:0019227] silver  
1
  • Ortholog Compara
Positive regulation of axon regenerationdefinition[GO:0048680] silver  
1
  • Ortholog Compara
Positive regulation of sequestering of calcium iondefinition[GO:0051284]  
1
  • BHF-UCL
Protein maturation by protein foldingdefinition[GO:0022417]  
1
  • BHF-UCL
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
2
  • BHF-UCL
  • GOC
Protein refoldingdefinition[GO:0042026]  
1
  • BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
2
  • Ortholog Curator
  • RefGenome
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0010880]  
1
  • BHF-UCL
Contradiction  Regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060314]  
3
  • BHF-UCL
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0014808] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to hydrogen peroxidedefinition[GO:0042542] silver  
1
  • Ortholog Compara
Response to redox statedefinition[GO:0051775]  
1
  • BHF-UCL
Response to vitamin Edefinition[GO:0033197] silver  
1
  • Ortholog Compara
Smooth muscle contractiondefinition[GO:0006939] silver  
1
  • Ortholog Compara
T cell proliferationdefinition[GO:0042098] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
1
  • UniProtKB
It is regulated in the following manner
Inhibited by both FK506 and rapamycin.  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP1B
GenomeRNAi: 2281
PRO: PR:P68106