TUBA4A - Tubulin alpha-4A chain - human protein (Function)
 
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TUBA4A »  Tubulin alpha-4A chain
 
Protein also known as:  Testis-specific alpha-tubulin.
Gene name:  TUBA4A
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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1 47 1
GENE REF ISO

Function

 show evidences
Overview 
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAInterPro 2 GO
GO biological process 
Microtubule-based processdefinition[GO:0007017] silver  
  • IEAInterPro 2 GO
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+7277  
Pathogenic Escherichia coli infection  hsa05130+7277  
Phagosome  hsa04145+7277  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Developmental Biology  REACT_111045  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Metabolism of proteins  REACT_17015  
Mitotic M-M/G1 phases  REACT_21300  
Note 
This tubulin does not have a C-terminal tyrosine.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TUBA4A
GenomeRNAi: 7277
PRO: PR:P68366