TUBA4A - Tubulin alpha-4A chain - human protein (Function)
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TUBA4A »  Tubulin alpha-4A chain
Protein also known as:  Testis-specific alpha-tubulin.
Gene name:  TUBA4A
Family name: Tubulin
Entry whose protein(s) existence is based on evidence at protein level
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Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
GTPase activitydefinition[GO:0003924] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Structural constituent of cytoskeletondefinition[GO:0005200] silver  
  • IEAInterPro 2 GO
GO biological process 
GTP catabolic processdefinition[GO:0006184] silver  
  • IEAInterPro 2 GO
Microtubule-based processdefinition[GO:0007017] silver  
  • IEAInterPro 2 GO
Protein polymerizationdefinition[GO:0051258] silver  
  • IEAInterPro 2 GO
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+7277  
Pathogenic Escherichia coli infection  hsa05130+7277  
Phagosome  hsa04145+7277  
According to Reactome, this protein belongs to the following pathways:
Formation of tubulin folding intermediates by CCT/TriC  REACT_16956  
Gap junction assembly  REACT_9509  
Kinesins  REACT_25201  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
MHC class II antigen presentation  REACT_121399  
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane  REACT_11039  
Mitotic Prometaphase  REACT_682  
Post-chaperonin tubulin folding pathway  REACT_16967  
Prefoldin mediated transfer of substrate to CCT/TriC  REACT_16936  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Recruitment of NuMA to mitotic centrosomes  REACT_15510  
Recycling pathway of L1  REACT_22365  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Resolution of Sister Chromatid Cohesion  REACT_150425  
Separation of Sister Chromatids  REACT_150471  
Translocation of GLUT4 to the plasma membrane  REACT_147867  
This tubulin does not have a C-terminal tyrosine.  
  • CuratedUniProtKB


Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: TUBA4A
GenomeRNAi: 7277
PRO: PR:P68366