HBB - Hemoglobin subunit beta - human protein (Function)
 
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HBB »  Hemoglobin subunit beta
 
Cleaved into:  LVV-hemorphin-7; Spinorphin.
Gene name:  HBB
Family name: Globin
Entry whose protein(s) existence is based on evidence at protein level
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1 479 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in oxygen transport from the lung to the various peripheral tissues.  
2
  • CuratedUniProtKB
LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.  
2
  • CuratedUniProtKB
Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.  
2
  • CuratedUniProtKB
GO molecular function 
Contributes to haptoglobin bindingdefinition[GO:0031720]  
1
  • IDABHF-UCL
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Hemoglobin bindingdefinition[GO:0030492]  
1
  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxygen bindingdefinition[GO:0019825]  
1
  • IDAUniProtKB
Oxygen transporter activitydefinition[GO:0005344]  
2
  • NASUniProtKB
Contributes to peroxidase activitydefinition[GO:0004601]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
11
  • IPIIntAct
GO biological process 
Hydrogen peroxide catabolic processdefinition[GO:0042744]  
1
  • IDABHF-UCL
Nitric oxide transportdefinition[GO:0030185]  
1
  • NASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAGOC
Oxygen transportdefinition[GO:0015671]  
3
  • NASUniProtKB
Positive regulation of cell deathdefinition[GO:0010942]  
1
  • IDABHF-UCL
Positive regulation of nitric oxide biosynthetic processdefinition[GO:0045429]  
1
  • NASUniProtKB
Protein heterooligomerizationdefinition[GO:0051291]  
1
  • IDABHF-UCL
Regulation of blood pressuredefinition[GO:0008217]  
  • IEAUniProtKB KW
Regulation of blood vessel sizedefinition[GO:0050880]  
  • IEAUniProtKB KW
Renal absorptiondefinition[GO:0070293]  
2
  • IMPUniProtKB
Response to hydrogen peroxidedefinition[GO:0042542]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3043  
Malaria  hsa05144+3043  
According to Reactome, this protein belongs to the following pathways:
Erythrocytes take up carbon dioxide and release oxygen  REACT_121329  
Erythrocytes take up oxygen and release carbon dioxide  REACT_121380  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Scavenging of heme from plasma  REACT_160163  
 

Keywords

Biological process 
Oxygen transport  definition   [KW-0561]
Transport  definition   [KW-0813]
Molecular function 
Hypotensive agent  definition   [KW-0382]
Vasoactive  definition   [KW-0838]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HBB
GenomeRNAi: 3043
PRO: PR:P68871