SIRPA - Tyrosine-protein phosphatase non-receptor type substrate 1 - human protein (Function)
 
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Protein
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SIRPA »  Tyrosine-protein phosphatase non-receptor type substrate 1  (SHPS-1)
 
Protein also known as:  Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD antigen CD172a.
Gene name:  SIRPA
Entry whose protein(s) existence is based on evidence at protein level
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1 80 3
GENE REF ISO

Function

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Overview 
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.  
2
  • CuratedUniProtKB
GO molecular function 
SH3 domain bindingdefinition[GO:0017124]  
  • IEAUniProtKB KW
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Osteoclast differentiation  hsa04380+140885  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Signal regulatory protein (SIRP) family interactions  REACT_23916  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links