CYP4F2 - Leukotriene-B(4) omega-hydroxylase 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CYP4F2 »  Leukotriene-B(4) omega-hydroxylase 1   [ EC 1.14.13.30 ]
 
Protein also known as:  Leukotriene-B(4) 20-monooxygenase 1.
Gene name:  CYP4F2
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 1
GENE REF ISO

Function

 show evidences
Overview 
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.  
  • CuratedUniProtKB
GO molecular function 
Alkane 1-monooxygenase activitydefinition[GO:0018685]  
1
  • IDABHF-UCL
Alpha-tocopherol omega-hydroxylase activitydefinition[GO:0052871]  
1
  • IDAUniProtKB
Arachidonic acid epoxygenase activitydefinition[GO:0008392]  
2
  • IDAUniProtKB
Arachidonic acid omega-hydroxylase activitydefinition[GO:0052869]  
2
  • IDAUniProtKB
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Leukotriene-B4 20-monooxygenase activitydefinition[GO:0050051]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Tocotrienol omega-hydroxylase activitydefinition[GO:0052872]  
1
  • IDAUniProtKB
Vitamin-K-epoxide reductase (warfarin-sensitive) activitydefinition[GO:0047057]  
1
  • IMPUniProtKB
GO biological process 
Arachidonic acid metabolic processdefinition[GO:0019369]  
1
  • IDAUniProtKB
Drug metabolic processdefinition[GO:0017144]  
2
  • IMPUniProtKB
Epoxygenase P450 pathwaydefinition[GO:0019373]  
2
  • IDAUniProtKB
Leukotriene B4 catabolic processdefinition[GO:0036101]  
3
  • IDAUniProtKB
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDABHF-UCL
Negative regulation of blood coagulationdefinition[GO:0030195]  
1
  • IMPUniProtKB
Negative regulation of icosanoid secretiondefinition[GO:0032304]  
1
  • IMPUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
3
  • IDAUniProtKB
Positive regulation of icosanoid secretiondefinition[GO:0032305]  
1
  • IMPUniProtKB
Pressure natriuresisdefinition[GO:0003095]  
1
  • IEPUniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
1
  • IMPUniProtKB
Renal water homeostasisdefinition[GO:0003091]  
1
  • IEPUniProtKB
Sodium ion homeostasisdefinition[GO:0055078]  
1
  • IEPUniProtKB
Very long-chain fatty acid metabolic processdefinition[GO:0000038]  
1
  • IDABHF-UCL
Vitamin E metabolic processdefinition[GO:0042360]  
1
  • IDAUniProtKB
Vitamin K biosynthetic processdefinition[GO:0042371]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.30: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+8529  
Metabolic pathways  hsa01100+8529  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYP4F2
GenomeRNAi: 8529
PRO: PR:P78329