RPP38 - Ribonuclease P protein subunit p38 - human protein (Function)
 
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RPP38 »  Ribonuclease P protein subunit p38   [ EC 3.1.26.5 ]  (RNaseP protein p38)
 
Gene name:  RPP38
Family name: Ribosomal protein L7Ae
Entry whose protein(s) existence is based on evidence at protein level
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1 23 1
GENE REF ISO

Function

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Overview 
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Ribonuclease P activitydefinition[GO:0004526]  
  • IEAEC 2 GO
GO biological process 
Nucleic acid phosphodiester bond hydrolysisdefinition[GO:0090305]  
1
  • TASGOC
RNA phosphodiester bond hydrolysisdefinition[GO:0090501]  
1
  • TASGOC
RNA phosphodiester bond hydrolysis, endonucleolyticdefinition[GO:0090502]  
1
  • TASGOC
tRNA processingdefinition[GO:0008033]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.26.5: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Ribosome biogenesis in eukaryotes  hsa03008+10557  
RNA transport  hsa03013+10557  
 

Keywords

Biological process 
tRNA processing  definition   [KW-0819]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RPP38
GenomeRNAi: 10557
PRO: PR:P78345