ABCA4 - Retinal-specific ATP-binding cassette transporter - human protein (Function)
 
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Protein
Gene
References

 
ABCA4 »  Retinal-specific ATP-binding cassette transporter
 
Protein also known as:  ATP-binding cassette sub-family A member 4.
Gene name:  ABCA4
Family name: ABC transporter » ABCA
Entry whose protein(s) existence is based on evidence at protein level
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1 140 1
GENE REF ISO

Function

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Overview 
In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.211.2  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IEAInterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012] silver  
  • IEAOrtholog Compara
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • TASGOC
Phospholipid transfer to membranedefinition[GO:0006649] silver  
  • IEAOrtholog Compara
Photoreceptor cell maintenancedefinition[GO:0045494] silver  
  • IEAOrtholog Compara
Transportdefinition[GO:0006810]  
1
  • TASPINC
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
ABC transporters  hsa02010+24  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCA4
GenomeRNAi: 24
PRO: PR:P78363