CSNK1G2 - Casein kinase I isoform gamma-2 - human protein (Function)
 
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CSNK1G2 »  Casein kinase I isoform gamma-2
 
Gene name:  CSNK1G2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.  
5
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAOrtholog Compara
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Phosphoprotein bindingdefinition[GO:0051219] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASUniProtKB
GO biological process 
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hedgehog signaling pathway  hsa04340+1455  
According to Reactome, this protein belongs to the following pathways:
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
Sphingolipid de novo biosynthesis  REACT_115810  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 1455
PRO: PR:P78368
Chemistry
GuidetoPHARMACOLOGY: 2000