OLR1 - Oxidized low-density lipoprotein receptor 1 - human protein (Function)
 
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OLR1 »  Oxidized low-density lipoprotein receptor 1  (Ox-LDL receptor 1)
 
Protein also known as:  C-type lectin domain family 8 member A. Cleaved into:  Oxidized low-density lipoprotein receptor 1, soluble form.
Gene name:  OLR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 168 3
GENE REF ISO

Function

 show evidences
Overview 
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.  
3
  • CuratedUniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Low-density lipoprotein receptor activitydefinition[GO:0005041] silver  
  • IEAOrtholog Compara
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Cell deathdefinition[GO:0008219] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Leukocyte cell-cell adhesiondefinition[GO:0007159] silver  
  • IEAOrtholog Compara
Lipoprotein metabolic processdefinition[GO:0042157] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • TASPINC
Response to hydrogen peroxidedefinition[GO:0042542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Phagosome  hsa04145+4973  
PPAR signaling pathway  hsa03320+4973  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: OLR1
GenomeRNAi: 4973
PRO: PR:P78380