CCNA1 - Cyclin-A1 - human protein (Function)
 
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CCNA1 »  Cyclin-A1
 
Gene name:  CCNA1
Family name: Cyclin » Cyclin AB
Entry whose protein(s) existence is based on evidence at protein level
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1 61 3
GENE REF ISO

Function

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Overview 
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAInterPro 2 GO
GO biological process 
Male meiosis Idefinition[GO:0007141]  
1
  • TASPINC
Mitotic nuclear divisiondefinition[GO:0007067]  
  • IEAUniProtKB KW
Regulation of cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0000079] silver  
  • IEAInterPro 2 GO
Regulation of G2/M transition of mitotic cell cycledefinition[GO:0010389] silver  
  • IEAInterPro 2 GO
Spermatogenesisdefinition[GO:0007283]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+8900  
Cell cycle  hsa04110+8900  
Pathways in cancer  hsa05200+8900  
Progesterone-mediated oocyte maturation  hsa04914+8900  
According to Reactome, this protein belongs to the following pathways:
Cyclin A/B1 associated events during G2/M transition  REACT_1857  
Cyclin A:Cdk2-associated events at S phase entry  REACT_9029  
DNA Damage/Telomere Stress Induced Senescence  REACT_169185  
E2F mediated regulation of DNA replication  REACT_471  
G0 and Early G1  REACT_111214  
G1/S-Specific Transcription  REACT_683  
G2 Phase  REACT_1915  
Orc1 removal from chromatin  REACT_1156  
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes  REACT_6362  
Regulation of APC/C activators between G1/S and early anaphase  REACT_6837  
SCF(Skp2)-mediated degradation of p27/p21  REACT_9003  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Cyclin  definition   [KW-0195]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cyclin_A1
GenomeRNAi: 8900
PRO: PR:P78396