CX3CL1 - Fractalkine - human protein (Function)
 
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CX3CL1 »  Fractalkine
 
Protein also known as:  CX3C membrane-anchored chemokine. Cleaved into:  Processed fractalkine.
Gene name:  CX3CL1
Family name: Intercrine delta
Entry whose protein(s) existence is based on evidence at protein level
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1 17 1
GENE REF ISO

Function

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Overview 
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.  
1
  • CuratedUniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • TASUniProtKB
GO biological process 
Angiogenesis involved in wound healingdefinition[GO:0060055] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Chemotaxisdefinition[GO:0006935]  
1
  • IDAUniProtKB
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • TASUniProtKB
Defense responsedefinition[GO:0006952]  
1
  • TASUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • TASUniProtKB
Leukocyte adhesive activationdefinition[GO:0050902]  
1
  • TASUniProtKB
Leukocyte chemotaxisdefinition[GO:0030595]  
1
  • TASUniProtKB
Lymphocyte chemotaxisdefinition[GO:0048247] silver  
  • IEAOrtholog Compara
Macrophage chemotaxisdefinition[GO:0048246] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240] silver  
  • IEAOrtholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Positive regulation of calcium-independent cell-cell adhesiondefinition[GO:0051041]  
1
  • IDAUniProtKB
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • IEPUniProtKB
Positive regulation of transforming growth factor beta1 productiondefinition[GO:0032914] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+6376  
Cytokine-cytokine receptor interaction  hsa04060+6376  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Chemotaxis  definition   [KW-0145]
Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CX3CL1
GenomeRNAi: 6376
PRO: PR:P78423