KCNJ10 - ATP-sensitive inward rectifier potassium channel 10 - human protein (Function)
 
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Protein
Gene
References

 
KCNJ10 »  ATP-sensitive inward rectifier potassium channel 10
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 10.
Gene name:  KCNJ10
Entry whose protein(s) existence is based on evidence at protein level
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1 38 1
GENE REF ISO

Function

 show evidences
Overview 
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-activated inward rectifier potassium channel activitydefinition[GO:0015272]  
1
  • TASPINC
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Central nervous system myelinationdefinition[GO:0022010] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
L-glutamate uptake involved in synaptic transmissiondefinition[GO:0051935] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Optic nerve developmentdefinition[GO:0021554] silver  
  • IEAOrtholog Compara
Potassium ion homeostasisdefinition[GO:0055075] silver  
  • IEAOrtholog Compara
Potassium ion importdefinition[GO:0010107] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
  • IEAOrtholog Compara
Regulation of resting membrane potentialdefinition[GO:0060075] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Response to blue lightdefinition[GO:0009637] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Gastric acid secretion  hsa04971+3766  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ10
GenomeRNAi: 3766
PRO: PR:P78508
Chemistry
GuidetoPHARMACOLOGY: 438