KCNJ10 - ATP-sensitive inward rectifier potassium channel 10 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
KCNJ10 »  ATP-sensitive inward rectifier potassium channel 10
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 10.
Gene name:  KCNJ10
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 50 1
GENE REF ISO

Function

 show evidences
Overview 
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATP-activated inward rectifier potassium channel activitydefinition[GO:0015272]  
1
  • PINC
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Receptor bindingdefinition[GO:0005102] silver  
1
  • Ortholog Compara
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
1
  • Ortholog Compara
Central nervous system myelinationdefinition[GO:0022010] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
L-glutamate uptake involved in synaptic transmissiondefinition[GO:0051935] silver  
1
  • Ortholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
1
  • Ortholog Compara
Optic nerve developmentdefinition[GO:0021554] silver  
1
  • Ortholog Compara
Potassium ion homeostasisdefinition[GO:0055075] silver  
1
  • Ortholog Compara
Potassium ion importdefinition[GO:0010107]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Protein homotetramerizationdefinition[GO:0051289] silver  
1
  • Ortholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • RefGenome
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Regulation of resting membrane potentialdefinition[GO:0060075] silver  
1
  • Ortholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Response to blue lightdefinition[GO:0009637] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to mineralocorticoiddefinition[GO:0051385] silver  
1
  • Ortholog Compara
Visual perceptiondefinition[GO:0007601] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Gastric acid secretion  hsa04971+3766  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Potassium transport channels  REACT_75815  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ10
GenomeRNAi: 3766
PRO: PR:P78508
Chemistry
GuidetoPHARMACOLOGY: 438