RELN - Reelin - human protein (Function)
 
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RELN »  Reelin   [ EC 3.4.21.- ]
 
Gene name:  RELN
Family name: Reelin
Entry whose protein(s) existence is based on evidence at protein level
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1 137 3
GENE REF ISO

Function

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Overview 
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).  
1
  • UniProtKB
GO molecular function 
Lipoprotein particle receptor bindingdefinition[GO:0070325]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • Ortholog Curator
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • UniProtKB KW
Very-low-density lipoprotein particle receptor bindingdefinition[GO:0070326]  
1
  • BHF-UCL
GO biological process 
Associative learningdefinition[GO:0008306] silver  
1
  • Ortholog Compara
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Brain developmentdefinition[GO:0007420]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell morphogenesis involved in differentiationdefinition[GO:0000904]  
1
  • Ortholog Curator
Central nervous system developmentdefinition[GO:0007417]  
1
  • Ortholog Curator
Cerebral cortex tangential migrationdefinition[GO:0021800]  
1
  • Ortholog Curator
Dendrite developmentdefinition[GO:0016358] silver  
1
  • Ortholog Compara
Glial cell differentiationdefinition[GO:0010001]  
1
  • Ortholog Curator
Hippocampus developmentdefinition[GO:0021766]  
1
  • Ortholog Curator
Lateral motor column neuron migrationdefinition[GO:0097477] silver  
1
  • Ortholog Compara
Layer formation in cerebral cortexdefinition[GO:0021819] silver  
1
  • Ortholog Compara
Long-term memorydefinition[GO:0007616] silver  
1
  • Ortholog Compara
N-methyl-D-aspartate receptor clusteringdefinition[GO:0097114] silver  
1
  • Ortholog Compara
Neuron migrationdefinition[GO:0001764]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • Ortholog Curator
Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000969]  
1
  • Ortholog Curator
Positive regulation of CREB transcription factor activitydefinition[GO:0032793]  
1
  • Ortholog Curator
Positive regulation of dendritic spine morphogenesisdefinition[GO:0061003]  
1
  • Ortholog Curator
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463]  
1
  • Ortholog Curator
Positive regulation of lateral motor column neuron migrationdefinition[GO:1902078] silver  
1
  • Ortholog Compara
Positive regulation of long-term synaptic potentiationdefinition[GO:1900273]  
1
  • Ortholog Curator
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • Ortholog Curator
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • Ortholog Curator
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • Ortholog Curator
Positive regulation of small GTPase mediated signal transductiondefinition[GO:0051057]  
1
  • Ortholog Curator
Positive regulation of synapse maturationdefinition[GO:0090129]  
1
  • Ortholog Curator
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968]  
1
  • Ortholog Curator
Positive regulation of TOR signalingdefinition[GO:0032008] silver  
1
  • Ortholog Compara
Postsynaptic density protein 95 clusteringdefinition[GO:0097119] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB KW
Receptor localization to synapsedefinition[GO:0097120] silver  
1
  • Ortholog Compara
Reelin-mediated signaling pathwaydefinition[GO:0038026]  
1
  • BHF-UCL
Regulation of behaviordefinition[GO:0050795]  
1
  • Ortholog Curator
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310]  
1
  • Ortholog Curator
Regulation of synaptic transmissiondefinition[GO:0050804]  
1
  • Ortholog Curator
Response to paindefinition[GO:0048265]  
1
  • Ortholog Curator
Spinal cord patterningdefinition[GO:0021511]  
1
  • Ortholog Curator
Ventral spinal cord developmentdefinition[GO:0021517] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+5649  
Focal adhesion  hsa04510+5649  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Developmental protein  definition   [KW-0217]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Reelin
GenomeRNAi: 5649
PRO: PR:P78509