RELN - Reelin - human protein (Function)
 
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RELN »  Reelin   [ EC 3.4.21.- ]
 
Gene name:  RELN
Family name: Reelin
Entry whose protein(s) existence is based on evidence at protein level
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1 122 3
GENE REF ISO

Function

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Overview 
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Lipoprotein particle receptor bindingdefinition[GO:0070325]  
1
  • ISSBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • ISSOrtholog Curator
Serine-type peptidase activitydefinition[GO:0008236]  
  • IEAUniProtKB KW
Very-low-density lipoprotein particle receptor bindingdefinition[GO:0070326]  
1
  • ISSBHF-UCL
GO biological process 
Associative learningdefinition[GO:0008306] silver  
  • IEAOrtholog Compara
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell morphogenesis involved in differentiationdefinition[GO:0000904]  
  • ISSOrtholog Curator
Central nervous system developmentdefinition[GO:0007417]  
  • ISSOrtholog Curator
Cerebral cortex tangential migrationdefinition[GO:0021800]  
  • ISSOrtholog Curator
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
Glial cell differentiationdefinition[GO:0010001]  
  • ISSOrtholog Curator
Hippocampus developmentdefinition[GO:0021766]  
  • ISSOrtholog Curator
Lateral motor column neuron migrationdefinition[GO:0097477] silver  
  • IEAOrtholog Compara
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
N-methyl-D-aspartate receptor clusteringdefinition[GO:0097114] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • ISSOrtholog Curator
Positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000969]  
  • ISSOrtholog Curator
Positive regulation of CREB transcription factor activitydefinition[GO:0032793]  
  • ISSOrtholog Curator
Positive regulation of dendritic spine morphogenesisdefinition[GO:0061003]  
  • ISSOrtholog Curator
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463]  
  • ISSOrtholog Curator
Positive regulation of lateral motor column neuron migrationdefinition[GO:1902078] silver  
  • IEAOrtholog Compara
Positive regulation of long-term synaptic potentiationdefinition[GO:1900273]  
  • ISSOrtholog Curator
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
  • ISSOrtholog Curator
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • ISSBHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase activitydefinition[GO:0045860]  
  • ISSOrtholog Curator
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
  • ISSOrtholog Curator
Positive regulation of small GTPase mediated signal transductiondefinition[GO:0051057]  
  • ISSOrtholog Curator
Positive regulation of synapse maturationdefinition[GO:0090129]  
  • ISSOrtholog Curator
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968]  
  • ISSOrtholog Curator
Positive regulation of TOR signalingdefinition[GO:0032008] silver  
  • IEAOrtholog Compara
Postsynaptic density protein 95 clusteringdefinition[GO:0097119] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Receptor localization to synapsedefinition[GO:0097120] silver  
  • IEAOrtholog Compara
Reelin-mediated signaling pathwaydefinition[GO:0038026]  
1
  • ISSBHF-UCL
Regulation of behaviordefinition[GO:0050795]  
  • ISSOrtholog Curator
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310]  
  • ISSOrtholog Curator
Regulation of synaptic transmissiondefinition[GO:0050804]  
  • ISSOrtholog Curator
Response to paindefinition[GO:0048265]  
  • ISSOrtholog Curator
Spinal cord patterningdefinition[GO:0021511]  
  • ISSOrtholog Curator
Ventral spinal cord developmentdefinition[GO:0021517] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+5649  
Focal adhesion  hsa04510+5649  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Developmental protein  definition   [KW-0217]
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Reelin
GenomeRNAi: 5649
PRO: PR:P78509