BLOC1S1 - Biogenesis of lysosome-related organelles complex 1 subunit 1 - human protein (Function)
 
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BLOC1S1 »  Biogenesis of lysosome-related organelles complex 1 subunit 1  (BLOC-1 subunit 1)
 
Protein also known as:  GCN5-like protein 1.
Gene name:  BLOC1S1
Family name: BLOC1S1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 2
GENE REF ISO

Function

 show evidences
Overview 
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Aerobic respirationdefinition[GO:0009060]  
1
  • IMPUniProtKB
Anterograde axon cargo transportdefinition[GO:0008089]  
  • ISSOrtholog Curator
Anterograde synaptic vesicle transportdefinition[GO:0048490]  
  • ISSOrtholog Curator
Melanosome organizationdefinition[GO:0032438]  
2
  • NASUniProtKB
Neuron projection developmentdefinition[GO:0031175]  
  • ISSOrtholog Curator
Peptidyl-lysine acetylationdefinition[GO:0018394]  
1
  • IMPUniProtKB
Platelet dense granule organizationdefinition[GO:0060155]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BLOC1S1
GenomeRNAi: 2647
PRO: PR:P78537