IL13RA1 - Interleukin-13 receptor subunit alpha-1 - human protein (Function)
 
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IL13RA1 »  Interleukin-13 receptor subunit alpha-1  (IL-13RA1)
 
Protein also known as:  Cancer/testis antigen 19 (CT19); CD antigen CD213a1.
Gene name:  IL13RA1
Entry whose protein(s) existence is based on evidence at protein level
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1 39 1
GENE REF ISO

Function

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Overview 
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.  
  • CuratedUniProtKB
GO molecular function 
Interleukin-13 receptor activitydefinition[GO:0016515] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Positive regulation of B cell proliferationdefinition[GO:0030890] silver  
  • IEAOrtholog Compara
Positive regulation of immunoglobulin productiondefinition[GO:0002639] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3597  
Jak-STAT signaling pathway  hsa04630+3597  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links