CCL20 - C-C motif chemokine 20 - human protein (Function)
 
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Protein
Gene
References

 
CCL20 »  C-C motif chemokine 20
 
Protein also known as:  Liver and activation-regulated chemokine. Cleaved into:  CCL20(1-64); CCL20(1-67); CCL20(2-70).
Gene name:  CCL20
Entry whose protein(s) existence is based on evidence at protein level
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1 133 2
GENE REF ISO

Function

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Overview 
Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.  
2
  • UniProtKB
GO molecular function 
CCR chemokine receptor bindingdefinition[GO:0048020]  
1
  • RefGenome
Chemokine activitydefinition[GO:0008009] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • RefGenome
Cellular response to interleukin-1definition[GO:0071347]  
1
  • RefGenome
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to lipoteichoic aciddefinition[GO:0071223] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356]  
1
  • RefGenome
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • RefGenome
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Defense response to bacteriumdefinition[GO:0042742]  
1
  • UniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • RefGenome
Immune responsedefinition[GO:0006955]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Lymphocyte chemotaxisdefinition[GO:0048247]  
1
  • RefGenome
Monocyte chemotaxisdefinition[GO:0002548]  
1
  • RefGenome
Neutrophil chemotaxisdefinition[GO:0030593]  
1
  • RefGenome
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • RefGenome
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • RefGenome
Positive regulation of interleukin-1 alpha biosynthetic processdefinition[GO:0050726] silver  
1
  • Ortholog Compara
Positive regulation of nitric-oxide synthase biosynthetic processdefinition[GO:0051770] silver  
1
  • Ortholog Compara
Positive regulation of T cell migrationdefinition[GO:2000406]  
1
  • MGI
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+6364  
Cytokine-cytokine receptor interaction  hsa04060+6364  
Rheumatoid arthritis  hsa05323+6364  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  R-HSA-380108  
G alpha (i) signalling events  R-HSA-418594  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Inflammatory response  definition   [KW-0395]
Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CCL20
GenomeRNAi: 6364
PRO: PR:P78556