PHEX - Phosphate-regulating neutral endopeptidase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PHEX »  Phosphate-regulating neutral endopeptidase   [ EC 3.4.24.- ]
 
Protein also known as:  Vitamin D-resistant hypophosphatemic rickets protein.
Gene name:  PHEX
Family name: Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 1
GENE REF ISO

Function

 show evidences
Overview 
Probably involved in bone and dentin mineralization and renal phosphate reabsorption.  
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASPINC
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Cellular protein modification processdefinition[GO:0006464]  
1
  • TASPINC
Organophosphate metabolic processdefinition[GO:0019637] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHEX
GenomeRNAi: 5251
PRO: PR:P78562