PHEX - Phosphate-regulating neutral endopeptidase - human protein (Function)
 
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PHEX »  Phosphate-regulating neutral endopeptidase   [ EC 3.4.24.- ]
 
Protein also known as:  Vitamin D-resistant hypophosphatemic rickets protein.
Gene name:  PHEX
Family name: Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probably involved in bone and dentin mineralization and renal phosphate reabsorption.  
1
  • UniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
1
  • UniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222] silver  
1
  • InterPro 2 GO
Zinc ion bindingdefinition[GO:0008270]  
1
  • PINC
GO biological process 
Bone mineralizationdefinition[GO:0030282] silver  
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  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
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  • PINC
Cellular protein modification processdefinition[GO:0006464]  
1
  • PINC
Organophosphate metabolic processdefinition[GO:0019637] silver  
1
  • Ortholog Compara
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
 
More information is available from:
 

Keywords

Biological process 
Biomineralization  definition   [KW-0091]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHEX
GenomeRNAi: 5251
PRO: PR:P78562