PHEX - Phosphate-regulating neutral endopeptidase - human protein (Sequence)
 
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PHEX »  Phosphate-regulating neutral endopeptidase   [ EC 3.4.24.- ]
 
Protein also known as:  Vitamin D-resistant hypophosphatemic rickets protein.
Gene name:  PHEX
Family name: Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 66 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   749 aaMass: 86474 Da,  pI: 8.91
MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD PWWSTESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW INDRRQGLEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA ISNFEEFQKA FNCPPNSTMN RGMDSCRLW

Keywords

Domain 
Signal-anchor  definition   [KW-0735]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.40.390.10
InterPro: IPR018497 [ Peptidase M13 C ]
InterPro: IPR008753 [ Peptidase M13 N ]
InterPro: IPR000718 [ Peptidase M13 ]
InterPro: IPR024079 [ MetalloPept cat dom ]
PANTHER: PTHR11733 [ PTHR11733 ]
PANTHER: PTHR11733:SF21 [ PTHR11733:SF21 ]
Pfam: PF05649 [ Peptidase M13 N ]
Pfam: PF01431 [ Peptidase M13 ]
PRINTS: PR00786 [ NEPRILYSIN ]
PROSITE: PS00142 [ ZINC PROTEASE ]
Genome annotation databases
Ensembl: Transcript: ENST00000379374;  Protein: ENSP00000368682;  Gene: ENSG00000102174.
Ensembl: Transcript: ENST00000537599;  Protein: ENSP00000440362;  Gene: ENSG00000102174.
Ensembl: Transcript: ENST00000535894;  Protein: ENSP00000439418;  Gene: ENSG00000102174.
Ensembl: Transcript: ENST00000418858;  Protein: ENSP00000443531;  Gene: ENSG00000102174.
KEGG: hsa:5251
UCSC: uc004dah.3
Organism-specific databases
MGI: MGI:107489 [ Phex ]
Other
ChiTaRS: PHEX
PTM databases
PhosphoSite: P78562
Phylogenomic databases
eggNOG: COG3590
HOGENOM: HOG000245574
HOVERGEN: HBG005554
InParanoid: P78562
KO: K08636
OMA: KVGYPEF
OrthoDB: EOG7PZRWQ
PhylomeDB: P78562
Sequence databases
CCDS: CCDS14204.1 [ P78562-1 ]
EMBL: mRNA:  U60475 . Translation:  AAC50552.1 .
EMBL: mRNA:  BC105059 . Translation:  AAI05060.1 .
EMBL: Genomic DNA:  AH004966 . Translation:  AAB42219.1 .
EMBL: mRNA:  U82970 . Translation:  AAC24487.1 .
EMBL: Genomic DNA:  Y10196 . Translation:  CAA71258.1 .
EMBL: mRNA:  U87284 . Translation:  AAB47562.1 .
EMBL: Genomic DNA:  Y08111 , Y08112 , Y08113 , Y08114 , Y08115 , Y08116 , Y08117 , Y08118 , Y08119 , Y08120 , Y08121 , Y08122 , Y08123 , Y08124 , Y08125 , Y08126 , Y08127 , Y08128 , Y08129 , Y08130 , Y08131 , Y08132 . Translation:  CAA69326.1 .
EMBL: mRNA:  AD000712 . Translation:  AAB51604.1 .
EMBL: Genomic DNA:  U73024 . Translation:  AAD08630.1 .
EMBL: mRNA:  U75645 . Translation:  AAB47749.1 .
EMBL: mRNA:  BC105057 . Translation:  AAI05058.1 .
IPI: IPI00020366
RefSeq: Protein:  NP_000435.3. Nucleotide sequence:  NM_000444.5.
RefSeq: Protein:  NP_001269683.1. Nucleotide sequence:  NM_001282754.1.
UniProtKB: P78562 [ PHEX ]