CXCL6 - C-X-C motif chemokine 6 - human protein (Function)
 
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Protein
Gene
References

 
CXCL6 »  C-X-C motif chemokine 6
 
Protein also known as:  Granulocyte chemotactic protein 2 (GCP-2). Cleaved into:  Small-inducible cytokine B6, N-processed variant 1; Small-inducible cytokine B6, N-processed variant 2; Small-inducible cytokine B6, N-processed variant 3.
Gene name:  CXCL6
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

 show evidences
Overview 
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).  
4
  • CuratedUniProtKB
GO molecular function 
Chemokine activitydefinition[GO:0008009] silver  
  • IEAInterPro 2 GO
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
GO biological process 
Cell chemotaxisdefinition[GO:0060326]  
1
  • TASGOC
  • IEAInterPro 2 GO
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Chemotaxisdefinition[GO:0006935]  
1
  • TASPINC
Defense response to bacteriumdefinition[GO:0042742]  
  • IEAUniProtKB KW
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+6372  
Cytokine-cytokine receptor interaction  hsa04060+6372  
Pertussis  hsa05133+6372  
Rheumatoid arthritis  hsa05323+6372  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6372
PRO: PR:P80162