ABAT - 4-aminobutyrate aminotransferase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
ABAT »  4-aminobutyrate aminotransferase, mitochondrial   [ EC 2.6.1.19 ]
 
Protein also known as:  (S)-3-amino-2-methylpropionate transaminase [EC 2.6.1.22].
Gene name:  ABAT
Entry whose protein(s) existence is based on evidence at protein level
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1 26 1
GENE REF ISO

Function

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Overview 
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.  
  • CuratedUniProtKB
GO molecular function 
(S)-3-amino-2-methylpropionate transaminase activitydefinition[GO:0047298]  
  • IEAEC 2 GO
Contributes to 4-aminobutyrate transaminase activitydefinition[GO:0003867]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170]  
1
  • IDAUniProtKB
Succinate-semialdehyde dehydrogenase bindingdefinition[GO:0032145]  
  • ISSOrtholog Curator
GO biological process 
Behavioral response to cocainedefinition[GO:0048148]  
  • ISSOrtholog Curator
Copulationdefinition[GO:0007620] silver  
  • IEAOrtholog Compara
Gamma-aminobutyric acid catabolic processdefinition[GO:0009450]  
1
  • NASUniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Neurotransmitter catabolic processdefinition[GO:0042135]  
1
  • NASUniProtKB
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.19: 4-aminobutanoate + 2-oxoglutarate succinate semialdehyde + L-glutamate.  
  • CuratedUniProtKB
EC 2.6.1.22: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate 2-methyl-3-oxopropanoate + L-glutamate.  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+18  
beta-Alanine metabolism  hsa00410+18  
Butanoate metabolism  hsa00650+18  
GABAergic synapse  hsa04727+18  
Metabolic pathways  hsa01100+18  
Propanoate metabolism  hsa00640+18  
Valine, leucine and isoleucine degradation  hsa00280+18  
According to Reactome, this protein belongs to the following pathway:
Degradation of GABA  REACT_23964  
 
More information is available from:
 

Keywords

Biological process 
Neurotransmitter degradation  definition   [KW-0531]
Molecular function 
Aminotransferase  definition   [KW-0032]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P80404
Other
GenomeRNAi: 18
PRO: PR:P80404
Chemistry
GuidetoPHARMACOLOGY: 2464