DEFB103A - Beta-defensin 103 - human protein (Function)
 
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Protein
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DEFB103A »  Beta-defensin 103
 
Protein also known as:  Defensin-like protein.
Gene name:  DEFB103A ; DEFB103B
Family name: Beta-defensin
Entry whose protein(s) existence is based on evidence at protein level
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2 89 1
GENE REF ISO

Function

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Overview 
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the pore-forming -defensin (-defensin) family  1.C.85.1.3  
GO biological process 
Defense response to bacteriumdefinition[GO:0042742]  
  • IEAUniProtKB KW
Positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriadefinition[GO:0006965]  
1
  • TASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Defensin  definition   [KW-0211]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DEFB103A
PRO: PR:P81534