CRB1 - Protein crumbs homolog 1 - human protein (Sequence)
 
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Protein
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References

 
CRB1 »  Protein crumbs homolog 1
 
Gene name:  CRB1
Family name: Crumbs protein
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 5
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   1406 aaMass: 154183 Da,  pI: 4.84
MALKNINYLL IFYLSFSLLI YIKNSFCNKN NTRCLSNSCQ NNSTCKDFSK DNDCSCSDTA NNLDKDCDNM KDPCFSNPCQ GSATCVNTPG ERSFLCKCPP GYSGTICETT IGSCGKNSCQ HGGICHQDPI YPVCICPAGY AGRFCEIDHD ECASSPCQNG AVCQDGIDGY SCFCVPGYQG RHCDLEVDEC ASDPCKNEAT CLNEIGRYTC ICPHNYSGVN CELEIDECWS QPCLNGATCQ DALGAYFCDC APGFLGDHCE LNTDECASQP CLHGGLCVDG ENRYSCNCTG SGFTGTHCET LMPLCWSKPC HNNATCEDSV DNYTCHCWPG YTGAQCEIDL NECNSNPCQS NGECVELSSE KQYGRITGLP SSFSYHEASG YVCICQPGFT GIHCEEDVNE CSSNPCQNGG TCENLPGNYT CHCPFDNLSR TFYGGRDCSD ILLGCTHQQC LNNGTCIPHF QDGQHGFSCL CPSGYTGSLC EIATTLSFEG DGFLWVKSGS VTTKGSVCNI ALRFQTVQPM ALLLFRSNRD VFVKLELLSG YIHLSIQVNN QSKVLLFISH NTSDGEWHFV EVIFAEAVTL TLIDDSCKEK CIAKAPTPLE SDQSICAFQN SFLGGLPVGM TSNGVALLNF YNMPSTPSFV GCLQDIKIDW NHITLENISS GSSLNVKAGC VRKDWCESQP CQSRGRCINL WLSYQCDCHR PYEGPNCLRE YVAGRFGQDD STGYVIFTLD ESYGDTISLS MFVRTLQPSG LLLALENSTY QYIRVWLERG RLAMLTPNSP KLVVKFVLND GNVHLISLKI KPYKIELYQS SQNLGFISAS TWKIEKGDVI YIGGLPDKQE TELNGGFFKG CIQDVRLNNQ NLEFFPNPTN NASLNPVLVN VTQGCAGDNS CKSNPCHNGG VCHSRWDDFS CSCPALTSGK ACEEVQWCGF SPCPHGAQCQ PVLQGFECIA NAVFNGQSGQ ILFRSNGNIT RELTNITFGF RTRDANVIIL HAEKEPEFLN ISIQDSRLFF QLQSGNSFYM LSLTSLQSVN DGTWHEVTLS MTDPLSQTSR WQMEVDNETP FVTSTIATGS LNFLKDNTDI YVGDRAIDNI KGLQGCLSTI EIGGIYLSYF ENVHGFINKP QEEQFLKIST NSVVTGCLQL NVCNSNPCLH GGNCEDIYSS YHCSCPLGWS GKHCELNIDE CFSNPCIHGN CSDRVAAYHC TCEPGYTGVN CEVDIDNCQS HQCANGATCI SHTNGYSCLC FGNFTGKFCR QSRLPSTVCG NEKTNLTCYN GGNCTEFQTE LKCMCRPGFT GEWCEKDIDE CASDPCVNGG LCQDLLNKFQ CLCDVAFAGE RCEVDLADDL ISDIFTTIGS VTVALLLILL LAIVASVVTS NKRATQGTYS PSRQEKEGSR VEMWNLMPPP AMERLI

Sequence

 show evidences
PTM 
Extensively glycosylated.  
  • CuratedUniProtKB
Sequence caution 
The sequence CAE45845 differs from that shown. Reason: erroneous termination at position 567.Translated as Trp.  
  • CuratedUniProtKB
The sequence CAI16644 differs from that shown. Reason: erroneous gene model prediction.  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
EGF-like domain  definition   [KW-0245]
Repeat  definition   [KW-0677]
Signal  definition   [KW-0732]
Transmembrane  definition   [KW-0812]
Transmembrane helix  definition   [KW-1133]
PTM 
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 2.60.120.200
InterPro: IPR013032 [ EGF-like CS ]
InterPro: IPR018097 [ EGF Ca-bd CS ]
InterPro: IPR013320 [ ConA-like subgrp ]
InterPro: IPR001881 [ EGF-like Ca-bd dom ]
InterPro: IPR000742 [ EG-like dom ]
InterPro: IPR000152 [ EGF-type Asp/Asn hydroxyl site ]
InterPro: IPR008985 [ ConA-like lec gl sf ]
InterPro: IPR009030 [ Growth fac rcpt N dom ]
InterPro: IPR001791 [ Laminin G ]
Pfam: PF12661 [ hEGF ]
Pfam: PF02210 [ Laminin G 2 ]
Pfam: PF00008 [ EGF ]
PROSITE: PS01187 [ EGF CA ]
PROSITE: PS50026 [ EGF 3 ]
PROSITE: PS50025 [ LAM G DOMAIN ]
PROSITE: PS00022 [ EGF 1 ]
PROSITE: PS00010 [ ASX HYDROXYL ]
PROSITE: PS01186 [ EGF 2 ]
SMART: SM00282 [ LamG ]
SMART: SM00181 [ EGF ]
SMART: SM00179 [ EGF CA ]
SUPFAM: SSF57184 [ SSF57184 ]
SUPFAM: SSF49899 [ SSF49899 ]
Genome annotation databases
Ensembl: Transcript: ENST00000484075;  Protein: ENSP00000433932;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000367400;  Protein: ENSP00000356370;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000367399;  Protein: ENSP00000356369;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000367397;  Protein: ENSP00000356367;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000448952;  Protein: ENSP00000395407;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000538660;  Protein: ENSP00000438091;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000535699;  Protein: ENSP00000438786;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000543483;  Protein: ENSP00000439579;  Gene: ENSG00000134376.
Ensembl: Transcript: ENST00000544212;  Protein: ENSP00000444556;  Gene: ENSG00000134376.
KEGG: hsa:23418
UCSC: uc001gtz.3
UCSC: uc010ppb.2
UCSC: uc001gub.1
UCSC: uc009wza.3
Organism-specific databases
MGI: MGI:2136343 [ Crb1 ]
PTM databases
PhosphoSite: P82279
Phylogenomic databases
eggNOG: NOG12793
HOVERGEN: HBG080001
InParanoid: P82279
KO: K16681
OMA: QSICAFQ
OrthoDB: EOG7KH9HX
PhylomeDB: P82279
Sequence databases
CCDS: CCDS53454.1 [ P82279-3 ]
CCDS: CCDS58052.1 [ P82279-5 ]
CCDS: CCDS1390.1 [ P82279-1 ]
EMBL: mRNA:  BC136271 . Translation:  AAI36272.1 .
EMBL: mRNA:  AJ748821 . Translation:  CAG38658.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAH72584.1 .
EMBL: Genomic DNA:  AL136322 . Translation:  CAI16644.1 . Sequence problems.
EMBL: mRNA:  AY043323 . Translation:  AAL10680.1 .
EMBL: mRNA:  AF154671 . Translation:  AAF01361.1 .
EMBL: Genomic DNA:  CH471067 . Translation:  EAW91277.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 . Translation:  CAI15310.1 .
EMBL: mRNA:  AK299368 . Translation:  BAH13018.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAI16646.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 . Translation:  CAI16645.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAM21656.1 .
EMBL: mRNA:  AY043324 . Translation:  AAL10681.1 .
EMBL: mRNA:  AY043325 . Translation:  AAL10682.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAM23328.1 .
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAM17208.1 .
EMBL: Genomic DNA:  AL356315 . No translation available.
EMBL: mRNA:  BX640729 . Translation:  CAE45845.1 . Sequence problems.
EMBL: Genomic DNA:  AL136322 , AL139136 , AL513325 . Translation:  CAI15311.1 .
IPI: IPI00607891
IPI: IPI00015785
IPI: IPI00397504
IPI: IPI00607552
RefSeq: Protein:  NP_001180569.1. Nucleotide sequence:  NM_001193640.1.
RefSeq: Protein:  NP_001244895.1. Nucleotide sequence:  NM_001257966.1.
RefSeq: Protein:  NP_001244894.1. Nucleotide sequence:  NM_001257965.1.
RefSeq: Protein:  NP_957705.1. Nucleotide sequence:  NM_201253.2.
UniProtKB: P82279 [ CRB1 ]