SMAD3 - Mothers against decapentaplegic homolog 3 - human protein (Function)
 
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SMAD3 »  Mothers against decapentaplegic homolog 3  (Mad3)
 
Protein also known as:  SMAD family member 3 (Smad3).
Gene name:  SMAD3
Family name: Dwarfin/SMAD
Entry whose protein(s) existence is based on evidence at protein level
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1 326 4
GENE REF ISO

Function

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Overview 
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.  
11
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIBHF-UCL
Chromatin DNA bindingdefinition[GO:0031490] silver  
  • IEAOrtholog Compara
Co-SMAD bindingdefinition[GO:0070410]  
4
  • IPIBHF-UCL
Collagen bindingdefinition[GO:0005518] silver  
  • IEAOrtholog Compara
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
2
  • IDAUniProtKB
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
35
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Contributes to protein binding transcription factor activitydefinition[GO:0000988]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
R-SMAD bindingdefinition[GO:0070412]  
1
  • IPIBHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDABHF-UCL
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
4
  • IDAUniProtKB
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • IPIBHF-UCL
Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activitydefinition[GO:0030618]  
1
  • IDABHF-UCL
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IDAUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
2
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IMPBHF-UCL
Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:0097296] silver  
  • IEAOrtholog Compara
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IMPBHF-UCL
Cell cycle arrestdefinition[GO:0007050]  
1
  • IMPBHF-UCL
Cell-cell junction organizationdefinition[GO:0045216]  
1
  • IMPBHF-UCL
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
  • IEAOrtholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617] silver  
  • IEAOrtholog Compara
Embryonic pattern specificationdefinition[GO:0009880] silver  
  • IEAOrtholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Evasion or tolerance of host defenses by virusdefinition[GO:0019049]  
1
  • IDABHF-UCL
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IMPBHF-UCL
Heart loopingdefinition[GO:0001947] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • IMPBHF-UCL
Immune system developmentdefinition[GO:0002520] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAGOC
Lens fiber cell differentiationdefinition[GO:0070306] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of mitotic cell cycledefinition[GO:0045930]  
1
  • IMPBHF-UCL
Negative regulation of osteoblast differentiationdefinition[GO:0045668] silver  
  • IEAOrtholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689] silver  
  • IEAOrtholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IMPBHF-UCL
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IMPBHF-UCL
Negative regulation of wound healingdefinition[GO:0061045] silver  
  • IEAOrtholog Compara
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • IMPBHF-UCL
Osteoblast developmentdefinition[GO:0002076] silver  
  • IEAOrtholog Compara
Paraxial mesoderm morphogenesisdefinition[GO:0048340] silver  
  • IEAOrtholog Compara
Pericardium developmentdefinition[GO:0060039] silver  
  • IEAOrtholog Compara
Positive regulation of alkaline phosphatase activitydefinition[GO:0010694] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPBHF-UCL
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • IMPBHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
2
  • IDABHF-UCL
Positive regulation of focal adhesion assemblydefinition[GO:0051894] silver  
  • IEAOrtholog Compara
Positive regulation of gene expression involved in extracellular matrix organizationdefinition[GO:1901313]  
1
  • IMPBHF-UCL
Positive regulation of interleukin-1 beta productiondefinition[GO:0032731] silver  
  • IEAOrtholog Compara
Positive regulation of positive chemotaxisdefinition[GO:0050927] silver  
  • IEAOrtholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496] silver  
  • IEAOrtholog Compara
Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IDAUniProtKB
  • IMPBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IDABHF-UCL
Positive regulation of transforming growth factor beta3 productiondefinition[GO:0032916] silver  
  • IEAOrtholog Compara
Primary miRNA processingdefinition[GO:0031053]  
1
  • TASBHF-UCL
Protein stabilizationdefinition[GO:0050821]  
1
  • IMPBHF-UCL
Regulation of bindingdefinition[GO:0051098] silver  
  • IEAOrtholog Compara
Regulation of epithelial cell proliferationdefinition[GO:0050678] silver  
  • IEAOrtholog Compara
Regulation of immune responsedefinition[GO:0050776] silver  
  • IEAOrtholog Compara
Regulation of striated muscle tissue developmentdefinition[GO:0016202] silver  
  • IEAOrtholog Compara
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015]  
1
  • IMPBHF-UCL
Regulation of transforming growth factor beta2 productiondefinition[GO:0032909]  
1
  • IMPBHF-UCL
Response to hypoxiadefinition[GO:0001666]  
1
  • IMPBHF-UCL
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
SMAD protein complex assemblydefinition[GO:0007183]  
2
  • IDABHF-UCL
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Thyroid gland developmentdefinition[GO:0030878] silver  
  • IEAOrtholog Compara
Transdifferentiationdefinition[GO:0060290] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Transportdefinition[GO:0006810]  
1
  • IDABHF-UCL
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+4088  
Cell cycle  hsa04110+4088  
Chagas disease (American trypanosomiasis)  hsa05142+4088  
Chronic myeloid leukemia  hsa05220+4088  
Colorectal cancer  hsa05210+4088  
Endocytosis  hsa04144+4088  
HTLV-I infection  hsa05166+4088  
Pancreatic cancer  hsa05212+4088  
Pathways in cancer  hsa05200+4088  
TGF-beta signaling pathway  hsa04350+4088  
Wnt signaling pathway  hsa04310+4088  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Gene Expression  REACT_71  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links