FOXK1 - Forkhead box protein K1 - human protein (Function)
 
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FOXK1 »  Forkhead box protein K1
 
Protein also known as:  Myocyte nuclear factor (MNF).
Gene name:  FOXK1
Entry whose protein(s) existence is based on evidence at protein level
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1 36 2
GENE REF ISO

Function

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Overview 
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Muscle organ developmentdefinition[GO:0007517]  
  • IEAUniProtKB KW
Negative regulation of cell growthdefinition[GO:0030308] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357] silver  
  • IEAOrtholog Compara
Tissue developmentdefinition[GO:0009888] silver  
  • IBARefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Myogenesis  definition   [KW-0517]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXK1
GenomeRNAi: 221937
PRO: PR:P85037