SHC2 - SHC-transforming protein 2 - human protein (Function)
 
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Protein
Gene
References

 
SHC2 »  SHC-transforming protein 2
 
Protein also known as:  Src homology 2 domain-containing-transforming protein C2 (SH2 domain protein C2).
Gene name:  SHC2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+25759  
Chemokine signaling pathway  hsa04062+25759  
Chronic myeloid leukemia  hsa05220+25759  
ErbB signaling pathway  hsa04012+25759  
Focal adhesion  hsa04510+25759  
Glioma  hsa05214+25759  
Insulin signaling pathway  hsa04910+25759  
Natural killer cell mediated cytotoxicity  hsa04650+25759  
Neurotrophin signaling pathway  hsa04722+25759  
VEGF signaling pathway  hsa04370+25759  
According to Reactome, this protein belongs to the following pathways:
SHC-mediated signalling  REACT_661  
Signal attenuation  REACT_508  
Signalling to RAS  REACT_12033  
Note 
PubMed15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed12006576.  
2
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHC2
GenomeRNAi: 25759
PRO: PR:P98077