VLDLR - Very low-density lipoprotein receptor - human protein (Function)
 
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VLDLR »  Very low-density lipoprotein receptor  (VLDL-R)
 
Gene name:  VLDLR
Entry whose protein(s) existence is based on evidence at protein level
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1 72 2
GENE REF ISO

Function

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Overview 
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Apolipoprotein bindingdefinition[GO:0034185]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Calcium-dependent protein bindingdefinition[GO:0048306]  
1
  • IPIBHF-UCL
Glycoprotein bindingdefinition[GO:0001948]  
1
  • IPIBHF-UCL
Glycoprotein transporter activitydefinition[GO:0034437]  
1
  • IDABHF-UCL
Low-density lipoprotein receptor activitydefinition[GO:0005041]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Reelin receptor activitydefinition[GO:0038025]  
  • ISSOrtholog Curator
Very-low-density lipoprotein particle bindingdefinition[GO:0034189]  
1
  • IDABHF-UCL
Very-low-density lipoprotein particle receptor activitydefinition[GO:0030229]  
1
  • IDABHF-UCL
GO biological process 
Cholesterol metabolic processdefinition[GO:0008203]  
  • IEAUniProtKB KW
Glycoprotein transportdefinition[GO:0034436]  
1
  • IDABHF-UCL
Lipid transportdefinition[GO:0006869]  
  • IEAUniProtKB KW
Memorydefinition[GO:0007613]  
1
  • TASPINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Positive regulation of dendrite developmentdefinition[GO:1900006]  
  • ISSOrtholog Curator
Positive regulation of protein kinase activitydefinition[GO:0045860] silver  
  • IEAOrtholog Compara
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IDABHF-UCL
Reelin-mediated signaling pathwaydefinition[GO:0038026]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Ventral spinal cord developmentdefinition[GO:0021517] silver  
  • IEAOrtholog Compara
Very-low-density lipoprotein particle clearancedefinition[GO:0034447]  
1
  • IDABHF-UCL
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Endocytosis  definition   [KW-0254]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: VLDL_receptor
GenomeRNAi: 7436
PRO: PR:P98155