ARHGAP4 - Rho GTPase-activating protein 4 - human protein (Function)
 
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ARHGAP4 »  Rho GTPase-activating protein 4
 
Protein also known as:  Rho-type GTPase-activating protein 4.
Gene name:  ARHGAP4
Entry whose protein(s) existence is based on evidence at protein level
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1 26 2
GENE REF ISO

Function

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Overview 
Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Rho GTPase activator activitydefinition[GO:0005100] silver  
  • IEAOrtholog Compara
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASPINC
GO biological process 
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASPINC
Negative regulation of axon extensiondefinition[GO:0030517] silver  
  • IEAOrtholog Compara
Negative regulation of fibroblast migrationdefinition[GO:0010764] silver  
  • IEAOrtholog Compara
Positive regulation of Rho GTPase activitydefinition[GO:0032321] silver  
  • IEAOrtholog Compara
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Rho protein signal transductiondefinition[GO:0007266]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGAP4
GenomeRNAi: 393
PRO: PR:P98171