EFNB1 - Ephrin-B1 - human protein (Function)
 
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Protein
Gene
References

 
EFNB1 »  Ephrin-B1
 
Protein also known as:  EPH-related receptor tyrosine kinase ligand 2 (LERK-2).
Gene name:  EFNB1
Family name: Ephrin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).  
1
  • UniProtKB
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).  
1
  • UniProtKB
GO molecular function 
Ephrin receptor bindingdefinition[GO:0046875]  
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  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
GO biological process 
Axon guidancedefinition[GO:0007411]  
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  • RefGenome
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Embryonic pattern specificationdefinition[GO:0009880] silver  
1
  • Ortholog Compara
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • RefGenome
Neural crest cell migrationdefinition[GO:0001755] silver  
1
  • Ortholog Compara
Positive regulation of T cell proliferationdefinition[GO:0042102] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+1947  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPH-Ephrin signaling  REACT_264068  
EPHB-mediated forward signaling  REACT_263952  
Ephrin signaling  REACT_264047  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EFNB1
GenomeRNAi: 1947
PRO: PR:P98172