ATP2C1 - Calcium-transporting ATPase type 2C member 1 - human protein (Function)
 
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ATP2C1 »  Calcium-transporting ATPase type 2C member 1   [ EC 3.6.3.8 ]  (ATPase 2C1)
 
Protein also known as:  ATP-dependent Ca(2+) pump PMR1.
Gene name:  ATP2C1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 9
GENE REF ISO

Function

 show evidences
Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.2.5  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
2
  • IDAUniProtKB
  • IEAUniProtKB KW
Isoforms  Iso 1 , Iso 5 and Iso 6   Calcium ion bindingdefinition[GO:0005509]  
2
  • IDAUniProtKB
Isoforms  Iso 1 , Iso 3 , Iso 4 , Iso 5 , Iso 6 , Iso 7 , Iso 8 and Iso 9 but not isoform  Iso 2   Calcium-transporting ATPase activitydefinition[GO:0005388]  
4
  • IDAUniProtKB
Isoform  Iso 6   Manganese ion bindingdefinition[GO:0030145]  
1
  • IDAUniProtKB
Isoform  Iso 6   Manganese-transporting ATPase activitydefinition[GO:0015410]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IMPUniProtKB
Calcium ion transmembrane transportdefinition[GO:0070588]  
4
  • IDAGOC
  • IEAEC 2 GO
  • IEAInterPro 2 GO
Calcium ion transportdefinition[GO:0006816]  
4
  • IDAUniProtKB
Calcium-dependent cell-cell adhesiondefinition[GO:0016339]  
1
  • IMPUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
3
  • IDAUniProtKB
Isoform  Iso 6   Cellular manganese ion homeostasisdefinition[GO:0030026]  
1
  • IDAUniProtKB
Epidermis developmentdefinition[GO:0008544]  
1
  • IMPUniProtKB
Golgi calcium ion homeostasisdefinition[GO:0032468]  
1
  • IMPUniProtKB
Golgi calcium ion transportdefinition[GO:0032472]  
1
  • IMPUniProtKB
Isoform  Iso 6   Manganese ion transmembrane transportdefinition[GO:0071421]  
1
  • IDAGOC
Isoform  Iso 6   Manganese ion transportdefinition[GO:0006828]  
1
  • IDAUniProtKB
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IMPGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2C1
GenomeRNAi: 27032
PRO: PR:P98194