ATP11A - Probable phospholipid-transporting ATPase IH - human protein (Function)
 
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ATP11A »  Probable phospholipid-transporting ATPase IH   [ EC 3.6.3.1 ]
 
Protein also known as:  P4-ATPase flippase complex alpha subunit ATP11A.
Gene name:  ATP11A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cation-transporting ATPase activitydefinition[GO:0019829] silver  
  • IEAInterPro 2 GO
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Phospholipid-translocating ATPase activitydefinition[GO:0004012]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
GO biological process 
Cation transportdefinition[GO:0006812] silver  
  • IEAInterPro 2 GO
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Phospholipid translocationdefinition[GO:0045332]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.1: ATP + H(2)O + phospholipid(Side 1) ADP + phosphate + phospholipid(Side 2).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
Note 
Overexpression of ATP11A confers resistance to lonafarnib.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Lipid transport  definition   [KW-0445]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 23250
PRO: PR:P98196