TFAM - Transcription factor A, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
TFAM »  Transcription factor A, mitochondrial  (mtTFA)
 
Protein also known as:  Mitochondrial transcription factor 1 (MtTF1).
Gene name:  TFAM
Entry whose protein(s) existence is based on evidence at protein level
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1 43 2
GENE REF ISO

Function

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Overview 
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.  
7
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • UniProtKB
DNA binding, bendingdefinition[GO:0008301]  
1
  • UniProtKB
Heat shock protein bindingdefinition[GO:0031072] silver  
1
  • Ortholog Compara
Mitochondrial light strand promoter sense bindingdefinition[GO:0070363]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • GO curators
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
GO biological process 
Chromatin remodelingdefinition[GO:0006338]  
1
  • RefGenome
DNA-dependent DNA replicationdefinition[GO:0006261]  
1
  • PINC
Mitochondrial respiratory chain complex assemblydefinition[GO:0033108] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Regulation of transcription from RNA polymerase I promoterdefinition[GO:0006356]  
1
  • PINC
Transcription from mitochondrial promoterdefinition[GO:0006390]  
1
  • UniProtKB
Transcription initiation from mitochondrial promoterdefinition[GO:0006391]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+7019  
According to Reactome, this protein belongs to the following pathways:
Mitochondrial transcription initiation  REACT_367  
Transcriptional activation of mitochondrial biogenesis  REACT_264212  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TFAM
GenomeRNAi: 7019
PRO: PR:Q00059