TFAM - Transcription factor A, mitochondrial - human protein (Function)
 
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Protein
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References

 
TFAM »  Transcription factor A, mitochondrial  (mtTFA)
 
Protein also known as:  Mitochondrial transcription factor 1 (MtTF1).
Gene name:  TFAM
Entry whose protein(s) existence is based on evidence at protein level
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1 39 2
GENE REF ISO

Function

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Overview 
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.  
6
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAUniProtKB
DNA binding, bendingdefinition[GO:0008301]  
1
  • IDAUniProtKB
Heat shock protein bindingdefinition[GO:0031072] silver  
  • IEAOrtholog Compara
Mitochondrial light strand promoter sense bindingdefinition[GO:0070363]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IMPUniProtKB
GO biological process 
DNA-dependent DNA replicationdefinition[GO:0006261]  
1
  • TASPINC
Mitochondrial respiratory chain complex assemblydefinition[GO:0033108] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of transcription from RNA polymerase I promoterdefinition[GO:0006356]  
1
  • TASPINC
Transcription from mitochondrial promoterdefinition[GO:0006390]  
1
  • IMPUniProtKB
Transcription initiation from mitochondrial promoterdefinition[GO:0006391]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Huntington's disease  hsa05016+7019  
According to Reactome, this protein belongs to the following pathways:
Mitochondrial transcription initiation  REACT_367  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TFAM
GenomeRNAi: 7019
PRO: PR:Q00059