CDK3 - Cyclin-dependent kinase 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CDK3 »  Cyclin-dependent kinase 3   [ EC 2.7.11.22 ]
 
Protein also known as:  Cell division protein kinase 3.
Gene name:  CDK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 1
GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
G0 to G1 transitiondefinition[GO:0045023]  
1
  • TASUniProtKB
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • TASUniProtKB
Mitosisdefinition[GO:0007067]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cyclin-dependent_kinase_3
GenomeRNAi: 1018
PRO: PR:Q00526
Chemistry
GuidetoPHARMACOLOGY: 1975