CDK16 - Cyclin-dependent kinase 16 - human protein (Function)
 
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CDK16 »  Cyclin-dependent kinase 16   [ EC 2.7.11.22 ]
 
Protein also known as:  Serine/threonine-protein kinase PCTAIRE-1.
Gene name:  CDK16
Entry whose protein(s) existence is based on evidence at protein level
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1 62 3
GENE REF ISO

Function

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Overview 
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
GO biological process 
Exocytosisdefinition[GO:0006887]  
  • ISSOrtholog Curator
Growth hormone secretiondefinition[GO:0030252]  
  • ISSOrtholog Curator
Neuron projection developmentdefinition[GO:0031175]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of cell cycledefinition[GO:0051726]  
  • IEAEC 2 GO
Regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061178]  
1
  • IMPUniProtKB
Spermatogenesisdefinition[GO:0007283]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
3
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PCTK1
GenomeRNAi: 5127
PRO: PR:Q00536
Chemistry
GuidetoPHARMACOLOGY: 1969