CLTC - Clathrin heavy chain 1 - human protein (Function)
 
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CLTC »  Clathrin heavy chain 1
 
Protein also known as:  Clathrin heavy chain on chromosome 17 (CLH-17).
Gene name:  CLTC
Family name: Clathrin heavy chain
Entry whose protein(s) existence is based on evidence at protein level
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1 109 2
GENE REF ISO

Function

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Overview 
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.  
  • CuratedUniProtKB
GO molecular function 
Clathrin light chain bindingdefinition[GO:0032051]  
1
  • IPIFlyBase
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • IDAMGI
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Structural molecule activitydefinition[GO:0005198]  
1
  • NASUniProtKB
GO biological process 
Intracellular protein transportdefinition[GO:0006886]  
1
  • NASUniProtKB
Mitosisdefinition[GO:0007067]  
1
  • IMPUniProtKB
Negative regulation of hyaluronan biosynthetic processdefinition[GO:1900126]  
2
  • IMPUniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • IMPBHF-UCL
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IMPUniProtKB
Transferrin transportdefinition[GO:0033572]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+1213  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+1213  
Endocytosis  hsa04144+1213  
Huntington's disease  hsa05016+1213  
Lysosome  hsa04142+1213  
Synaptic vesicle cycle  hsa04721+1213  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLTC
GenomeRNAi: 1213
PRO: PR:Q00610