CLTC - Clathrin heavy chain 1 - human protein (Function)
 
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CLTC »  Clathrin heavy chain 1
 
Protein also known as:  Clathrin heavy chain on chromosome 17 (CLH-17).
Gene name:  CLTC
Family name: Clathrin heavy chain
Entry whose protein(s) existence is based on evidence at protein level
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1 134 2
GENE REF ISO

Function

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Overview 
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.  
1
  • UniProtKB
GO molecular function 
Clathrin light chain bindingdefinition[GO:0032051]  
1
  • FlyBase
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • MGI
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • Ortholog Curator
Structural molecule activitydefinition[GO:0005198]  
1
  • UniProtKB
GO biological process 
Intracellular protein transportdefinition[GO:0006886]  
1
  • UniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB
Negative regulation of hyaluronan biosynthetic processdefinition[GO:1900126]  
2
  • UniProtKB
Negative regulation of protein localization to plasma membranedefinition[GO:1903077]  
1
  • UniProtKB
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • BHF-UCL
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • UniProtKB
Transferrin transportdefinition[GO:0033572]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+1213  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+1213  
Endocytosis  hsa04144+1213  
Huntington's disease  hsa05016+1213  
Lysosome  hsa04142+1213  
Synaptic vesicle cycle  hsa04721+1213  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_228189  
Formation of annular gap junctions  REACT_11049  
Gap junction degradation  REACT_11035  
Golgi Associated Vesicle Biogenesis  REACT_19400  
Lysosome Vesicle Biogenesis  REACT_19287  
MHC class II antigen presentation  REACT_121399  
WNT5A-dependent internalization of FZD4  REACT_172599  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLTC
GenomeRNAi: 1213
PRO: PR:Q00610