FKBP3 - Peptidyl-prolyl cis-trans isomerase FKBP3 - human protein (Function)
 
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FKBP3 »  Peptidyl-prolyl cis-trans isomerase FKBP3   [ EC 5.2.1.8 ]  (PPIase FKBP3)
 
Protein also known as:  Rapamycin-selective 25 kDa immunophilin.
Gene name:  FKBP3
Family name: FKBP-type PPIase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

 show evidences
Overview 
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.  
  • CuratedUniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528] silver  
  • IBARefGenome
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755] silver  
  • IBARefGenome
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Peptidyl-proline modificationdefinition[GO:0018208] silver  
  • IBARefGenome
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited preferentially by rapamycin over FK506.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP3
GenomeRNAi: 2287
PRO: PR:Q00688