CACNA1B - Voltage-dependent N-type calcium channel subunit alpha-1B - human protein (Function)
 
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CACNA1B »  Voltage-dependent N-type calcium channel subunit alpha-1B
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide isoform 5.
Gene name:  CACNA1B
Entry whose protein(s) existence is based on evidence at protein level
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1 38 2
GENE REF ISO

Function

 show evidences
Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
High voltage-gated calcium channel activitydefinition[GO:0008331] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • TASPINC
GO biological process 
Calcium ion importdefinition[GO:0070509] silver  
  • IBARefGenome
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Neurotransmitter secretiondefinition[GO:0007269] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of heart contractiondefinition[GO:0008016] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Response to paindefinition[GO:0048265] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+774  
Cholinergic synapse  hsa04725+774  
Dopaminergic synapse  hsa04728+774  
GABAergic synapse  hsa04727+774  
MAPK signaling pathway  hsa04010+774  
Synaptic vesicle cycle  hsa04721+774  
Taste transduction  hsa04742+774  
Type II diabetes mellitus  hsa04930+774  
According to Reactome, this protein belongs to the following pathway:
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: N-type_calcium_channel
GenomeRNAi: 774
PRO: PR:Q00975
Chemistry
GuidetoPHARMACOLOGY: 533