IRF9 - Interferon regulatory factor 9 - human protein (Function)
 
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Protein
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References

 
IRF9 »  Interferon regulatory factor 9  (IRF-9)
 
Protein also known as:  IFN-alpha-responsive transcription factor subunit.
Gene name:  IRF9
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
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1 34 1
GENE REF ISO

Function

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Overview 
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Regulatory region DNA bindingdefinition[GO:0000975] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Defense response to virusdefinition[GO:0051607]  
  • IEAUniProtKB KW
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Type I interferon biosynthetic processdefinition[GO:0045351] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hepatitis C  hsa05160+10379  
Herpes simplex infection  hsa05168+10379  
Influenza A  hsa05164+10379  
Jak-STAT signaling pathway  hsa04630+10379  
Measles  hsa05162+10379  
Osteoclast differentiation  hsa04380+10379  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ISGF3G
GeneWiki: IRF9
GenomeRNAi: 10379
PRO: PR:Q00978