PDE1B - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PDE1B »  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B   [ EC 3.1.4.17 ]  (Cam-PDE 1B)
 
Protein also known as:  63 kDa Cam-PDE.
Gene name:  PDE1B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 25 2
GENE REF ISO

Function

 show evidences
Overview 
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.  
1
  • CuratedUniProtKB
GO molecular function 
3',5'-cyclic-AMP phosphodiesterase activitydefinition[GO:0004115] silver  
  • IEAOrtholog Compara
Calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activitydefinition[GO:0048101] silver  
  • IEAOrtholog Compara
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent cyclic-nucleotide phosphodiesterase activitydefinition[GO:0004117]  
1
  • TASPINC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
cAMP catabolic processdefinition[GO:0006198]  
1
  • IDAUniProtKB
Cellular response to granulocyte macrophage colony-stimulating factor stimulusdefinition[GO:0097011]  
1
  • IDAUniProtKB
Cellular response to macrophage colony-stimulating factor stimulusdefinition[GO:0036006]  
1
  • IDAUniProtKB
cGMP catabolic processdefinition[GO:0046069]  
1
  • IDAUniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Monocyte differentiationdefinition[GO:0030224]  
1
  • IEPUniProtKB
Regulation of dopamine metabolic processdefinition[GO:0042053] silver  
  • IEAOrtholog Compara
Regulation of neurotransmitter levelsdefinition[GO:0001505] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Serotonin metabolic processdefinition[GO:0042428] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.17: Nucleoside 3',5'-cyclic phosphate + H(2)O nucleoside 5'-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5153  
Purine metabolism  hsa00230+5153  
According to Reactome, this protein belongs to the following pathways:
Cam-PDE 1 activation  REACT_15408  
cGMP effects  REACT_23767  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PDE1B
GenomeRNAi: 5153
PRO: PR:Q01064
Chemistry
GuidetoPHARMACOLOGY: 1295