E2F1 - Transcription factor E2F1 - human protein (Function)
 
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E2F1 »  Transcription factor E2F1  (E2F-1)
 
Protein also known as:  Retinoblastoma-associated protein 1 (RBAP-1).
Gene name:  E2F1
Family name: E2F/DP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed20176812).  
7
  • UniProtKB
GO molecular function 
Core promoter bindingdefinition[GO:0001047]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
3
  • UniProtKB
  • MGI
Protein bindingdefinition[GO:0005515]  
24
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • Ortholog Curator
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • UniProtKB
GO biological process 
Anoikisdefinition[GO:0043276] silver  
1
  • Ortholog Compara
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to nerve growth factor stimulusdefinition[GO:1990090] silver  
1
  • Ortholog Compara
Cellular response to xenobiotic stimulusdefinition[GO:0071466] silver  
1
  • Ortholog Compara
DNA damage checkpointdefinition[GO:0000077]  
1
  • UniProtKB
Forebrain developmentdefinition[GO:0030900] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway by p53 class mediatordefinition[GO:0072332] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • UniProtKB
Lens fiber cell apoptotic processdefinition[GO:1990086] silver  
1
  • Ortholog Compara
mRNA stabilizationdefinition[GO:0048255]  
1
  • BHF-UCL
Negative regulation of DNA bindingdefinition[GO:0043392]  
1
  • UniProtKB
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • Ortholog Curator
Negative regulation of fat cell proliferationdefinition[GO:0070345]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Negative regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0071930]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • UniProtKB
  • BHF-UCL
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • BHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • BHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • CACAO
  • BHF-UCL
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • BHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • Ortholog Curator
Enzymatic activity 
It is regulated in the following manner
BIRC2/c-IAP1 stimulates its transcriptional activity.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+1869  
Cell cycle  hsa04110+1869  
Chronic myeloid leukemia  hsa05220+1869  
Glioma  hsa05214+1869  
HTLV-I infection  hsa05166+1869  
Melanoma  hsa05218+1869  
Non-small cell lung cancer  hsa05223+1869  
Pancreatic cancer  hsa05212+1869  
Pathways in cancer  hsa05200+1869  
Prostate cancer  hsa05215+1869  
Small cell lung cancer  hsa05222+1869  
According to Reactome, this protein belongs to the following pathways:
Activation of NOXA and translocation to mitochondria  R-HSA-111448  
Activation of PUMA and translocation to mitochondria  R-HSA-139915  
Association of licensing factors with the pre-replicative complex  R-HSA-69298  
CDC6 association with the ORC:origin complex  R-HSA-68689  
Cyclin D associated events in G1  R-HSA-69231  
E2F mediated regulation of DNA replication  R-HSA-113510  
G0 and Early G1  R-HSA-1538133  
G1/S-Specific Transcription  R-HSA-69205  
G2 Phase  R-HSA-68911  
Inhibition of replication initiation of damaged DNA by RB1/E2F1  R-HSA-113501  
Oncogene Induced Senescence  R-HSA-2559585  
Oxidative Stress Induced Senescence  R-HSA-2559580  
Pre-NOTCH Transcription and Translation  R-HSA-1912408  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: E2F1
GenomeRNAi: 1869
PRO: PR:Q01094