SCN7A - Sodium channel protein type 7 subunit alpha - human protein (Function)
 
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SCN7A »  Sodium channel protein type 7 subunit alpha
 
Protein also known as:  Sodium channel protein cardiac and skeletal muscle subunit alpha.
Gene name:  SCN7A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  
  • CuratedUniProtKB
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248] silver  
  • IBARefGenome
GO biological process 
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Muscle contractiondefinition[GO:0006936] silver  
  • IEAInterPro 2 GO
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Sodium ion homeostasisdefinition[GO:0055078] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725] silver  
  • IBARefGenome
Sodium ion transportdefinition[GO:0006814]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCN7A
GenomeRNAi: 6332
PRO: PR:Q01118